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Cyclins: a structure and function

Cyclins: a structure and function. Anna Ajduk, Hulya Cabadak, Karolina Czaja, Heli Honkala, Stephen Huisman. Introduction. N. C. cyclin-box. N-domain (5 helices). C-domain (5 helices). Conserved domains and motifs.

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Cyclins: a structure and function

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  1. Cyclins: a structure and function Anna Ajduk, Hulya Cabadak, Karolina Czaja, Heli Honkala, Stephen Huisman

  2. Introduction

  3. N C cyclin-box N-domain (5 helices) C-domain (5 helices) Conserved domains and motifs R - x(2) - [LIVMSA] - x(2) - [FYWS] - [LIVM] - x(8) - [LIVMFC] - x (4) - [LIVMFYA] - x(2) - [STAGC] - [LIVMFYQ] - x - [LIVMFYC] - [LIVMFY] - D - [RKH] - [LIVMFYW]

  4. Structure of mouse cyclin B1

  5. Cyclins bind with cyclin-depended kinases (CDKs) and activate them: CycA – CDK 2 CycB – CDK1 CycD – CDK 4,5 CycE – CDK2 cyc CDK

  6. Cyclins bind with CDKs Crystal structure of cycA1 and CDK2 Model of cycB1 and CDK1

  7. nuclear localisation PLK cycB1 S126 S128 S133 S147 MAPK phosphorylation by Plk control G1/S progression turnover PKA GSK-3 cycD1 S90 S197 S234 T287 Cyclins are regulated by phosphorylation

  8. S- and M-phase cyclins contain a destruction box RTALGDIGN Hum-cycB1 Mou-cycB1 Xen-cycB1 Hum-cycA2 Mou-cycA2 RAALAVLKSGN cyc proteolysis

  9. Phylogenetic comparison

  10. Anna Heli Hulya Karolina Stephen Thank you, Tesekkurler, Dziekujemy, Kiitos, Bedankt

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