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HIVToolbox: An Integrated Web Application for Investigating HIV

HIVToolbox: An Integrated Web Application for Investigating HIV . David P. Sargeant , Sandeep Deverasetty , Yang Luo , Angel Villahoz-Baleta , Stephanie Zobrist , Viraj R. Rathnaayake , Jacquelie C. Russo, Jay Vyas , Christy Strong, Mark A. Muesing , Martin R. Schiller July 25, 2012.

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HIVToolbox: An Integrated Web Application for Investigating HIV

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  1. HIVToolbox: An Integrated Web Application for Investigating HIV David P. Sargeant, SandeepDeverasetty, Yang Luo, Angel Villahoz-Baleta, Stephanie Zobrist, Viraj R. Rathnaayake, Jacquelie C. Russo, Jay Vyas, Christy Strong, Mark A. Muesing, Martin R. Schiller July 25, 2012

  2. HIVToolbox for Sequence, Structure, and Function Integrated display: HIV-1 proteins, ~300,000 sequences,~700 structures, ~1000 activities, ~1500 mutations >16,000 searches Linked to PDB

  3. HIVToolbox2 for Drug Resistance 3JVY Flap Atazanavir Resistance Darunavir Binding Site Darunavir Resistance Active site Dimerization Primary Primary Set Beneficial Beneficial Set Secondary Indinavir Resistance fosAmprenavir Resistance Nelfinavir Resistance Lopinavir Resistance Conserved Tipranaivir Resistance >80% identity 50,000 isolates Ritonavir Resistance Saquinavir Resistance

  4. HIVGeoRes for Drug Resistance Darunavir Resistance Atazanavir Resistance fosAmprenavir Resistance IAVI Report, 2003 Indinavir Resistance Lopinavir Resistance Nelfinavir Resistance Geographic resistance profiles do not mimic subtype profiles • Hivtoolbox.bio-toolkit.com • Bio-toolkit.com • Sargeant et al. PLoS One 2011 Ritonavir Resistance Saquinavir Resistance Tipranaivir Resistance

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