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Jingyuan Yang Research Meeting 05/08/2008

A LOG-LINEAR APPROACH TO DEAL WITH MULTIPLE AFFECTED SIBLING IN DETECTING MATERNAL EFFECT AND PARENT-OF-ORIGIN EFFECT. Jingyuan Yang Research Meeting 05/08/2008. Risk Factors. (1) A person carries disease allele(s);

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Jingyuan Yang Research Meeting 05/08/2008

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  1. A LOG-LINEAR APPROACH TO DEAL WITH MULTIPLE AFFECTED SIBLING IN DETECTING MATERNAL EFFECT AND PARENT-OF-ORIGIN EFFECT Jingyuan Yang Research Meeting 05/08/2008

  2. Risk Factors (1) A person carries disease allele(s); (2) His or her mother carries disease allele(s) and passes some antigen or mRNA to the person during pregnancy which could increase the susceptibility of the person; (3) Interaction of (1) and (2): effect of a specific maternal-fetal genotype combination. Notes: Once (1) is detected as a risk factor, then origin of each allele comes into play as a secondary objective of investigation (parent-of-origin effect). Both (2) and (3) are considered as maternally “mediated” effect

  3. Schaid et al (1993): Genotype Relative Risks In this paper, only (1) was considered as the risk factor, i.e.: Relative risk is defined as the ratio between the disease susceptibility of two randomly selected persons who have different genetic backgrounds. They were: Data in this model are the counts of 6 different mating types

  4. Weinberg et al (1998) and Sinsheimer et al (2003) Weinberg’s LL-LRT: Sinsheimer’s MFG test:

  5. Maximize the Likelihood Direct approach Generalized linear approach

  6. Multiple Sibling

  7. Simulation Simulation was conducted by decomposing the likelihood in another way Compute , and simulate the parental genotypes according to the number of affected sibling in that family. Then Use P(C|M, F, D) to generate the genotype of each child in a nuclear family.

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