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Lecture 3

Lecture 3. CHE 618. Metabolism and transport Metabolism of common drugs Different routes of elimination Saturation kinetics . 0.05-0.10 mg/mL cocaine. ¼ mg /mL cocaine. benzoylecgonine. Cocaethylene. Ecgonine . Methylecgonine . 3-hydroxy-8-methyl-8-azabicyclo

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Lecture 3

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  1. Lecture 3 CHE 618

  2. Metabolism and transport Metabolism of common drugs Different routes of elimination Saturation kinetics

  3. 0.05-0.10 mg/mL cocaine ¼ mg /mL cocaine

  4. benzoylecgonine Cocaethylene Ecgonine Methylecgonine 3-hydroxy-8-methyl-8-azabicyclo [3.2.1]octane-2-carboxylic acid H

  5. Cocaine metabolic profile. BE-benzoylecgonine, EME-ecgonine methyl ester,CE- cocethylene

  6. 6-MAM morphine Methylmorphine(codeine)

  7. C2H5OH disulfiram Reduction

  8. Glucuronic acid Mechanism of glucurondation

  9. + Hippuric acid Hippo- horse + uric

  10. Saturation kinetics Zero order logC First order time

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