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Mg and Zn Modified Calcium Phosphate Ceramics

Mg and Zn Modified Calcium Phosphate Ceramics D . Rabadjieva 1 , S . Tepavitcharova 1 , R . Gergulova 1 , K . Sezanova 1 , R . Titorenkova 2 , E . Dyulgerova 3 , O . Petrov 2

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Mg and Zn Modified Calcium Phosphate Ceramics

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  1. Mg and Zn Modified Calcium Phosphate Ceramics D. Rabadjieva1, S. Tepavitcharova1, R. Gergulova1, K. Sezanova1, R. Titorenkova2, E. Dyulgerova3, O. Petrov2 1Institute of General and Inorganic Chemistry, Bulgarian Academy of Sciences,Acad. G. Bontchev Str., Bl.11, 1113 Sofia, Bulgaria didiarab@svr.igic.bas.bg 2 Institute of Mineralogy and Crystallography, Bulgarian Academy of Sciences, Acad. G. Bontchev Str., Bl.107, 1113 Sofia, Bulgaria 3Dental Medicine Faculty, University of Medicine, 1 G. Sofiiski Str., 1431 Sofia, Bulgaria INTRODUCTION PURPOSE EXPERIMENTS To exam the effect of Mg2+ or Zn2+ ion substitutions on the phase composition of calcium phosphate ceramics, their morphologycal and structural changes. • SBF (Na+, K+, Mg2+, Ca2+, Cl-, SO42-, CO32-, HPO42-) – CaCl2/ZnCl2/MgCl2 – K2HPO4 – KOH system • Initial Zn(Mg)/(Zn(Mg) +Ca) molar ratio: 0, 0.03, 0.13 • pH 8, room temperature; • Precipitation • Xanthan Gum gelling and Liophilization • Washing and Secondary liophilization • Sintering at 1000oC for 2 h Ion modified calcium phosphate-based ceramics are designed to simulate the mineral composition of the hard bone tissues or to strengthen some specific biologically important behaviour. The biological active Mg plays an important role in the formation and growth of the hard bone tissue and the Zn is extremely important mediator for more than 200 enzymes. RESULTS Chemical composition of the sintered at 1000oC solid phase XRD studies IR studies Zn2+/(Zn2++Ca2+) 0.13 0.03 0 SEM studies Zn- modified ceramics Mg – modified ceramics Mg2+/(Mg2++Ca2+) Mg-β-TCP + HA Zn- β-TCP Mg/(Mg +Ca) = 0.02 0.10 0.02 0 Zn/(Zn +Ca) = 0.03 Zn- β-TCP Mg- β-TCP Zn/(Zn +Ca) = 0.13 Mg/(Mg +Ca) = 0.10 ■ HA; -TCP; CONCLUSIONS Zn2+ ions substitution - Mono phased zinc-β-TCP ceramics with idiomorphic crystals (sizes 500–5000 nm). Mg2+ ions substitution - Concentration of Mg2+ ions is a crucial Mg2+/(Mg2+ +Ca2+) = 0.10 - mono phased magnesium-β-TCP ceramicswith spherical grains (sizes 100-500 nm); Mg2+/(Mg2+ +Ca2+) = 0.02 - bi-phased ceramics consisting of magnesium-β-TCP and hydroxiapatite (HA)(sizes 100-500 nm). Acknowledgements:This work was financially supported by the Bulgarian Ministry of Education, Youth and Science under contracts DTK - 0270/09 and CVP-09-0003

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