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I A. FFR and the New ESC Guidelines. FFR Awarded Strongest Recommendation, Highest Level of Evidence: I A. Key Points.
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I A FFR and the New ESC Guidelines FFR Awarded Strongest Recommendation, Highest Level of Evidence: I A
Key Points • Cardiologists and thoracic surgeons together, have written recommendations for when a patient should be revascularized (treated by PCI or CABG) rather than treated by optimal medical therapy alone. • New guidelines: Functional testing (non-invasive test or FFR) is key in determining whether or not a patient should be revascularized*. • FFR has been given the highest possible recommendation: Class ILevel of Evidence A * Wijns, et al., EurHeart J (2010) 31(20): 2501-2555 first published online August 29, 2010
Recommendation I A = Strongest I A = FFR is generally accepted as valuable; strong evidence exists to support its use. 4
FFR Should be Used Before Deciding on Treatment For the treating physician, the new guidelines mean that he should measure FFR before making a decision to perform PCI or send the patient to surgery, in patients who come to the cath lab without a prior functional test and with a stenosis(es)50-90% by angiography. This is regardless of whether the patient has single-vessel disease, multivessel disease, or if the vessel is especially important, eg. proximal LAD or LMCA. 5
FFR vs Other Functional Tests • Non-invasive tests • We know that in many countries, up to 50% of patients come to the coronary cath lab without any prior functional test1If results from a prior functional test are available, even in the case of the most sophisticated tests, the results are not always reliable, especially in multivessel disease. • FFR • A functional test that can be performed in the cath lab. • A specific functional test that is useful and reliable in the majority of patients. • The FAME Study2has shown that FFR reduces mortality, reduces costs and doesn’t increase procedure time.
References • Grace A. Lin; R. Adams Dudley; F. L. Lucas; et al. Prior to Elective Percutaneous Coronary Intervention Frequency of Stress Testing to Document Ischemia, JAMA. 2008;300(15):1765-1773 (doi:10.1001/jama.300.15.1765) • Pim A.L. Tonino, et al. Fractional Flow Reserve versus Angiography for Guiding Percutaneous Coronary Intervention. NEJM 2009;360;3:213-24 7