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kin17

kin17. Novel protein related to splicing/mRNA processing, transcription, and cell cycle regulation . Chromosomal proteins often interact with DNA to control maintenance, propagation, and expression of the genome.

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kin17

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  1. kin17 • Novel protein related to splicing/mRNA processing, transcription, and cellcycleregulation. • Chromosomal proteins often interact with DNA to control maintenance, propagation, and expression of the genome. • Kin17 forms intranuclear foci and accumulates in the nuclei of proliferating cells. • Cells presenting low levels of this protein also showed a prolongation of the S phase of the cell cycle associated with an accumulation of cells in early and mid-S phase, a decreased rate of DNA synthesis, and an increased sensitivity to gamma irradiation.

  2. Ultrastructuralcolocalization of kin17 protein with DNA replication proteins. kin17/RPA70 kin17/PCNA Human RKO cells kin17/DNA polymeraseα

  3. kin17 protein is a component of high-molecular-weight nuclear protein complexes.

  4. kin17 protein is a component of the MRC in human HeLa cells. suggesting that the kin17 protein might be a part of the MRC purifiedbyMono-Q chromatography

  5. kin17 protein copurifies with an RC complex from S-phase HeLa cells

  6. kin17 protein copurifies with an RC complex from S-phase HeLa cells 669 kDa RC complex

  7. Immunodepletion of kin17 protein inhibits in vitro replication of SV40 origin- and large T antigen-dependent DNA replication

  8. Direct involvement of kin17 protein in DNA replication Human Monkey

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