1 / 10

Lewis Triple Response

Lewis Triple Response. Described by sir Thomas Lewis in 1924. Lewis triple response is the characteristic 3 part response that develops when a line is made by a pointed object (a key) on the skin. It is produced due to the release of histamine from the mast cells.

tanika
Download Presentation

Lewis Triple Response

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Lewis Triple Response • Described by sir Thomas Lewis in 1924. • Lewis triple response is the characteristic 3 part response that develops when a line is made by a pointed object (a key) on the skin. It is produced due to the release of histamine from the mast cells.

  2. Trauma may release an antigen that interacts with the membrane-bound immunoglobulin E of mast cells, which release inflammatory mediators, particularly histamine, into the tissues. This causes small blood vessels to leak, allowing fluid to accumulate in the skin.

  3. Inflammatory Response

  4. Components of the Triple Response 1.Red reaction: red line (transient local vasodilation due to histamine), appears in few seconds. 2.Wheal: localized edema in the region of the redline (increased capillary permeability and exudation of fluid from capillaries and venules due to histamine release), appears in 1 min. 3.Flare:spreading redness extending beyond the red line (due to axon reflex), appears slowly.

  5. - Three cell types • smooth muscle in the microcirculation • endothelium: capillary or venule • sensory nerve endings

  6. Receptor types

  7. Subgroups of Histamine Receptor Blockers

  8. What will occur withAntihistamine ORLocal Anesthetics?

More Related