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Daniel E. Weeks Professor of Human Genetics and Biostatistics

Daniel E. Weeks Professor of Human Genetics and Biostatistics. 1983 B.A., summa cum laude, Biology and Mathematics, Colby College , Waterville, ME 1988 Ph.D., Biomathematics (Kenneth Lange, mentor ), UCLA

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Daniel E. Weeks Professor of Human Genetics and Biostatistics

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  1. Daniel E. WeeksProfessor of Human Genetics and Biostatistics • 1983 B.A., summa cum laude, Biology and Mathematics, Colby College, Waterville, ME • 1988 Ph.D., Biomathematics (Kenneth Lange, mentor), UCLA • 1989-90 Postdoctoral training in Statistical Genetics (JurgOtt, mentor), Columbia University • 1990 Joined the University of Pittsburgh • 1994-98WellcomeTrust Centre for Human Genetics, University of Oxford • 2001 The Mortimer Spiegelman Award • awarded by the American Public Health Association, for outstanding contributions in health statistics.

  2. Research Interests • Statistical Genetics and Genetic Epidemiology • New statistical methodology for linkage and association analysis • Validation and implementation in computer programs • Comparison of multiple methods on simulated data • Collaborative applied statistical genetics for a wide variety of traits

  3. Teaching • HuGen Fall Course • Quantitative Genetics • Linkage Analysis • Bioinformatics in Human Genetics (new course, to be offered Fall 2010) • India-US Research Training Program in Genetics (Fogarty Training Program; PI Weeks) • 5th Statistical Genetics Workshop, Feb 17-24, 2010 • Wellcome Trust Advanced Course, United Kingdom • Every July • Paris Workshops on Genetic Epidemiology, France • 2005, 2007, 2009, …

  4. Research • Genetics of age-related macular degeneration • Genetic database development • Mega2 (PI Weeks) • A data-handling program for facilitating genetic linkage and association analyses. • Dental caries genome-wide association study (GWA) • Pre-term birth GWA

  5. Research GWA of obesity-related traits in Samoans Age-related macular degeneration in African-Americans and Amish Food allergy GWA Alcoholism Pediatric Transplantation Otitismedia

  6. Collaborations • University of Pittsburgh, Northwestern University, University of Iowa • Samoan Study: • Brown University, University of Cincinnati • Fogarty Training Grant: • Indian Statistical Institute, Kolkata

  7. Publications of Interest • Jakobsdottir J, Gorin MB, Conley YP, Ferrell RE, Weeks DE (2009) Interpretation of genetic association studies: markers with replicated highly significant odds ratios may be poor classifiers. PLoS Genet 5:e1000337 • Casselbrant ML, Mandel EM, Jung J, Ferrell RE, Tekely K, Szatkiewicz JP, Ray A, Weeks DE (2009) Otitis media: a genome-wide linkage scan with evidence of susceptibility loci within the 17q12 and 10q22.3 regions. BMC Med Genet 10:85

  8. Publications of Interest • Mukhopadhyay I, Feingold E, Weeks DE, Thalamuthu A. Association tests using kernel-based measures of multi-locus genotype similarity between individuals. Genet Epidemiol. 2010 Apr;34(3):213-21.

  9. Opportunities • Applied statistical analyses of genetic data sets • Account for correlations due to relationships • Simulation studies comparing various statistical genetics methods • Development of new statistical algorithms for analyzing human genetic data • Skills: • Statistics • Computer programming • Mathematics • Data management • Population and human genetics

  10. The End

  11. Teaching • Mentoring • Chia-Ling Kuo, Biostatistics Ph.D. • Xinyu Tang, Biostatistics Ph.D. • UmutOzbek, Biostatistics Ph.D. • Helping, as needed, several on the GENEVA GWA projects. • Supervision • NanditaMukhopadhyay, programmer

  12. Service Chair, HuGen Admissions Committee Associate Editor, Statistical Applications in Genetics and Molecular Biology Editorial Board, Genetic Epidemiology (2005-08 Regular member, Genomics, Computational Biology and Technology (GCAT) NIH Study Section. )

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