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Membranes and Proteins

Membranes and Proteins. Matthew Sender Scientists as Teachers, Teachers as Scientists NSF GK12- Award # 0841377. Cell Membrane. Phospholipid bilayer. Lipid. Phospho. Layer 1. Layer 2. Two layers = bi layer. Why bother with two layers?. Water loving (hydrophilic) outside

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Membranes and Proteins

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  1. Membranes and Proteins Matthew Sender Scientists as Teachers, Teachers as Scientists NSF GK12- Award # 0841377

  2. Cell Membrane • Phospholipid bilayer Lipid Phospho Layer 1 Layer 2 Two layers = bilayer

  3. Why bother with two layers? Water loving (hydrophilic) outside Water fearing (hydrophobic) inside Fears water Loves water Layer 1 Layer 2

  4. Membrane Proteins • P60+61 in your book • Cell Surface Marker • Receptor Protein • Enzyme • Transport Protein http://en.wikipedia.org/wiki/File:Fluid_Mosaic.svg

  5. Membrane Proteins- Cell Surface Marker What blood type are you? Extracellular DOI:10.2210/pdb2edo/pdb

  6. Membrane Proteins- Receptor Protein Acetylcholine Receptor Extracellular Intracellular Do you like to move your muscles? 10.2210/pdb2bg9/pdb

  7. Receives a special molecule Opens the closed gate Extracellular End Intracellular End 10.2210/pdb2bg9/pdb

  8. Membrane Proteins- Enzyme Angiotensin II Makes a molecule that increases blood pressure

  9. Membrane Proteins- Transport Side View Top down When open allows sugars, salts, and amino acids to pass DOI:10.2210/pdb2jqy/pdb

  10. Summary • Proteins play a large role in the function of cells (therefore our lives) • Different types of protein structures have different functions • Small examples given there are many thousands of proteins in nature

  11. Protein Database Protein files are available for free at http://www.pdb.org/pdb/home/home.do I visualize them and make pictures of them using the software Chimera (free for academic use) http://www.cgl.ucsf.edu/chimera/download.html

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