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TRATAMIENTO DEL DOLOR EN NEUROPATIA DIABETICA

TRATAMIENTO DEL DOLOR EN NEUROPATIA DIABETICA. Acido alpha lipoico Oral Treatment With -Lipoic Acid Improves Symptomatic Diabetic Polyneuropathy . The SYDNEY 2 trial Diabetes Care 29:2365-2370, 2006

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TRATAMIENTO DEL DOLOR EN NEUROPATIA DIABETICA

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  1. TRATAMIENTO DEL DOLOREN NEUROPATIA DIABETICA

  2. Acido alpha lipoico • Oral Treatment With -Lipoic Acid Improves Symptomatic DiabeticPolyneuropathy. The SYDNEY 2 trial Diabetes Care 29:2365-2370, 2006 Oral treatment with ALA for 5 weeks improvedneuropathic symptoms and deficits in patients with DSP. An oraldose of 600 mg once daily appears to provide the optimum risk-to-benefitratio • Sola S, Mir MQ, Cheema FA, Khan-Merchant N, Menon RG, Parthasarathy S, Khan BV: Irbesartan and lipoic acid improve endothelial function and reduce markers of inflammation in the metabolic syndrome: results of the Irbesartan and Lipoic Acid in Endothelial Dysfunction (ISLAND) study. Circulation 111:343–348, 2005 In the Irbesartan and Lipoic Acid in Endothelial Dysfunction(ISLAND) study, oral administration of 300 mg ALA per day asmonotherapy and in combination with irbesartan (150 mg/day)to patients with the metabolic syndrome resulted in a significantincrease in endothelium-dependent flow-mediated vasodilationof the brachial artery by 44 and 75%, respectively, comparedwith placebo treatment after 4 weeks. This effect was accompaniedby reductions in plasma levels of interleukin-6 and plasminogenactivator-1, suggesting that the drug may improve endothelialdysfunction via anti-inflammatory and antithrombotic mechanisms • Nagamatsu M, Nickander KK, Schmelzer JD, Raya A, Wittrock DA, Tritschler HT, Low PA: Lipoic acid improves nerve blood flow, reduces oxidative stress and improves distal nerve conduction in experimental diabetic neuropathy. Diabetes Care 18:1160–1167, 1995

  3. Acetyl-L-carnitineimproves pain, nerve regeneration, and vibratory perception in patients with chronic diabetic neuropathy: an analysis of two randomized placebo-controlled trials.Sima AA, Calvani M, Mehra M, Amato A; Acetyl-L-Carnitine Study Group.Diabetes Care. 2005 Jan;28(1):89-94.1000 pacientes 500 – 1000mg/d por 52 semanas Acetyl-L-carnitinein the treatment of diabetic neuropathy. A long-term, randomised, double-blind, placebo-controlled study.De Grandis D, Minardi C.Drugs R D. 2002;3(4):223-31. Benfotiaminein the treatment of diabetic polyneuropathy--a three-week randomized, controlled pilot study (BEDIP study). Haupt E, Ledermann H, Köpcke W.Int J Clin Pharmacol Ther. 2005 Jun;43(6):304. Prodroga vit B1 liposoluble

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