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What are we learning from wildlife about endocrine disruption that is relevant to human health?

What are we learning from wildlife about endocrine disruption that is relevant to human health? . Dr. Peter L. deFur Center for Environmental Studies Virginia Commonwealth Univ June 20 2013. In A Word. Everything Well… Almost everything Considering all “not people” animals.

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What are we learning from wildlife about endocrine disruption that is relevant to human health?

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  1. What are we learning from wildlife about endocrine disruption that is relevant to human health? Dr. Peter L. deFur Center for Environmental Studies Virginia Commonwealth Univ June 20 2013

  2. In A Word Everything Well… Almost everything Considering all “not people” animals

  3. Pesticide companies have disrupted insect hormone systems for ca. 40 years All good science is a story – of inquiry and discovery Hormonal control of metamorphosis in insects is affected by molting (ecdysone) and juvenile hormones

  4. Ecdysone Tebufenozide Insect Juvenile Hormone

  5. The Story continues- pick up to the early 1990’s Beginning with wildlife in recent years Two clutches of eggs in one nest Cross-billed cormorant In 1993-6

  6. Model of how EDC acts on hormone-receptor interactions EDC hormone hormone EDC EDC R R R Mimic normal action Abnormal action Blocked action R= hormone receptor; EDC = endocrine disrupting chemical

  7. What can go wrong or awry with chemicals in the environment?

  8. Fish sex change First reported in Florida in 1970’s Male Goby fish showed female characteristics Downstream from pulp mill effluent Sitosterol was active chemical from trees Reported in other rivers with pulp effluent Resurfaced in England in 1995- thanks to John Sumpter

  9. “steroid” mechanism of action How does a system work? Second messenger mechanism

  10. Lessons thus far • Can synthesize hormones and mimics • Untimely exposures can harm • Endogenous hormones when exogenous— • Mechanisms and processes • Low levels can harm

  11. Ecy receptor RxR receptor

  12. 17B-Estradiol 20- hydroxyecdysone Diethylstilbestrol (DES) DDT Coumestrol

  13. 17 B estradiol 4-nonylphenol Ah receptor model BPA chlordecone Tributyltin

  14. Lessons learned- some too late • Biology is conserved • What can go wrong • How disruption occurs • New end points • New mechanisms • Indicators- the canary in the coal mine • Need confirmation from mammalian data

  15. Summary of lessons

  16. ? 42

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