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Nano + Bio technology. Akilbekova Dana. Dana Akilbekova. B.Sc. in Physics, al- Farabi KazNU , 2007 M.Sc. in Nanoscale Physics, Rice University, 2010 Research interests: Synthesis of nanoscale materials Composite materials Biophysics
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Nano + Biotechnology Akilbekova Dana
Dana Akilbekova • B.Sc. in Physics, al-FarabiKazNU, 2007 • M.Sc. in Nanoscale Physics, Rice University, 2010 Research interests: • Synthesis of nanoscale materials • Composite materials • Biophysics • Use of functionalized nanomaterials in the areas of biology sciences
Agenda: • Definition • Main research areas • Gold nanoshells • Protein transistors • Conclusion
Definition: Nanotechnology concerns itself with the study of objects which are anywhere from hundreds to tens of nanometers. Nanobiotechnology applies the tools and processes of nano/microfabrication to build devices for studying biosystems.
Gold Nanoshells: • Naomi Halas, Rice University, created nanoshells in 1997 • Imaging and destroying cancerous cells • The idea is that the nanoshells could attach to a tumor and, when hit by a certain type of light, heat up and kill cancer cells.
What�is special about a nanoshell? • Gold displays very strong surface plasmon resonance effects • Plasmons are quantized oscillations (waves) in the plasma (or electron gas) within a metal. • Gold nanoshells are tunable to different wavelengths of light • Near-infrared-light range • Plasmon resonance along both the inner and outer surfaces of the shell • Scientists were able to create drastic temperature differences at localized points in the body (35oC). Hirsch, L. R.; Stafford, R. J.; Bankson, J. A.; et al; Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance. 2003. Proc NatlAcadSci U S A, v.100(23); Nov 11, 2003.
Fabrication of nanoshells: • Grow or obtain a nanoparticle sized dielectric core (such as spheres of silica). • Chemically treat the surface of the core to make it "sticky" and ready coating with gold nanoparticles. • Grow gold "seed particles" on the surface of the core and then plate gold on top until a complete layer has formed
“Tune" them to absorb specific wavelengths of light • By thinning and roughening the surface of the nanoshell, scientists change the absorbed wavelength of light from visible wavelengths into the near infrared
Metalloprotein-based electronics devices: • Bioelectronics – nanoscale devices where single biomolecules can be used to transfer and process and electronic signal • Design: • Suitable bimolecular system • Immobilization of the molecule onto an electronic substrate • Interconnection to contacts • Device fabrication processing • Recognition of molecular information • Processing of information
Amplifying (transistor like) devices • It works at air and room temperature • Peculiar behavior of the protein devices that is not found in any inorganic devices • The results are far promising
Conclusion: There are a lot of another interesting examples: • Probing the interface of QDs with biomolecules and solid-state matrixes • Bioconjugation of functionalized nanoparticles • Manipulation of biomolecules using nanoparticles • Synchrotron X-ray visualization of cellular bioenergetic processes • Molecular signal transduction and cell actuation with nanoscale materials • Bio-inspired catalysis and photocatalysis • Metals in complex biological systems • Synthesis and characterization of nanoscale inorganic materials and bioinorganic hybrids and assembly in organized structures • …..