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Nano + Bio technology

Nano + Bio technology. Akilbekova Dana. Dana Akilbekova. B.Sc. in Physics, al- Farabi KazNU , 2007 M.Sc. in Nanoscale Physics, Rice University, 2010 Research interests: Synthesis of nanoscale materials Composite materials Biophysics

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Nano + Bio technology

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  1. Nano + Biotechnology Akilbekova Dana

  2. Dana Akilbekova • B.Sc. in Physics, al-FarabiKazNU, 2007 • M.Sc. in Nanoscale Physics, Rice University, 2010 Research interests: • Synthesis of nanoscale materials • Composite materials • Biophysics • Use of functionalized nanomaterials in the areas of biology sciences

  3. Agenda: • Definition • Main research areas • Gold nanoshells • Protein transistors • Conclusion

  4. Definition: Nanotechnology concerns itself with the study of objects which are anywhere from hundreds to tens of nanometers. Nanobiotechnology applies the tools and processes of nano/microfabrication to build devices for studying biosystems.

  5. Research areas:

  6. Gold Nanoshells: • Naomi Halas, Rice University, created nanoshells in 1997 • Imaging and destroying cancerous cells • The idea is that the nanoshells could attach to a tumor and, when hit by a certain type of light, heat up and kill cancer cells.

  7. What�is special about a nanoshell? • Gold displays very strong surface plasmon resonance effects • Plasmons are quantized oscillations (waves) in the plasma (or electron gas) within a metal. • Gold nanoshells are tunable to different wavelengths of light • Near-infrared-light range • Plasmon resonance along both the inner and outer surfaces of the shell • Scientists were able to create drastic temperature differences at localized points in the body (35oC). Hirsch, L. R.; Stafford, R. J.; Bankson, J. A.; et al; Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance. 2003. Proc NatlAcadSci U S A, v.100(23); Nov 11, 2003.

  8. Fabrication of nanoshells: • Grow or obtain a nanoparticle sized dielectric core (such as spheres of silica). • Chemically treat the surface of the core to make it "sticky" and ready coating with gold nanoparticles. • Grow gold "seed particles" on the surface of the core and then plate gold on top until a complete layer has formed

  9. “Tune" them to absorb specific wavelengths of light • By thinning and roughening the surface of the nanoshell, scientists change the absorbed wavelength of light from visible wavelengths into the near infrared

  10. Drug delivery and imaging system based on nanoshells:

  11. Metalloprotein-based electronics devices: • Bioelectronics – nanoscale devices where single biomolecules can be used to transfer and process and electronic signal • Design: • Suitable bimolecular system • Immobilization of the molecule onto an electronic substrate • Interconnection to contacts • Device fabrication processing • Recognition of molecular information • Processing of information

  12. Amplifying (transistor like) devices • It works at air and room temperature • Peculiar behavior of the protein devices that is not found in any inorganic devices • The results are far promising

  13. Conclusion: There are a lot of another interesting examples: • Probing the interface of QDs with biomolecules and solid-state matrixes • Bioconjugation of functionalized nanoparticles • Manipulation of biomolecules using nanoparticles • Synchrotron X-ray visualization of cellular bioenergetic processes • Molecular signal transduction and cell actuation with nanoscale materials • Bio-inspired catalysis and photocatalysis • Metals in complex biological systems • Synthesis and characterization of nanoscale inorganic materials and bioinorganic hybrids and assembly in organized structures • …..

  14. Thank you!

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