Teaching Bio-Transport Courses for Undergraduate and Graduate Students in ME and BME

1. Teaching Bio-Transport Courses for Undergraduate and Graduate Students in ME and BME Lisa Xuemin Xu, Ph.D. Med-X Research Institute & School of Biomedical Engineering Shanghai Jiao Tong University

2. Teaching Experiences • 500 Level Graduate Course in ME at Purdue (1997-2002) • Graduate Course in BME at Shanghai Jiao Tong Univ. (2003-present) • Undergraduate Course in BME at Shanghai Jiao Tong Univ. (2005-present)

3. Bio-Heat Transfer Course (Undergraduate) 2 Credits, FALL Semester Description: This course is designed for biomedical engineering undergraduates with necessary physics and mathematics background. A student achieving a passing grade in this course shall be able to use the basic bio-heat and mass transfer theories and method to analyze real biomedical problems, be familiar with important applications of bio-heat transfer.

4. COURSE TOPICS • Energy conservation and metabolisms • Basics of conduction, convection, radiation • Convection over body surface, sweating, respiration • Heat transfer to blood vessels • Thermal equilibration length of blood Vessel • Anatomy and description of human vasculature system • Temperature induced dynamic change of blood flow • Bio-heat Equation (Pennes Equation) • Temperature measurement and IR Detection of Breast Cancer • Application I: Tumor thermal treatment • Application II：Cryo-preservation

5. Textbook and References Text: • Thermal Dosimetry and Treatment Planning, JC Chato, KD Paulsen, RB Roemer, M. Gautherie (Ed.), Springer-Verlag Berlin Heidelberg New York, London, Paris, Tokyo, Hongkong, 1990 Reference books： • Heat Transfer in Medicine and Biology, A. Shitzer, Robert C. Eberhart, Plenum Press, New York and London, 1985 • Heat Transfer Essentials, Latif M. Jiji, Begell House Inc. Publishers, New York, 1998

8. Advanced Bio-heat and Mass Transfer (Graduate Course)3 Credits, Spring Semester Description: This course is for graduate students of biomedical engineering specialty. The aim of this course is to introduce advanced bio-heat and mass transfer problems and research fields. Upon completion of this course, students are expected to understand mechanisms underlying thermal physics interaction with biological systems, and more importantly, to be able to simulate, analyze and evaluate the transportation of heat and mass problems in this field.

9. Course Topics • Review of basic concepts • Bio-heat transfer equations：Pennes, WJ, Chen-Holmes Equation, different models • Biological responses to thermal stress • Advanced bio-heat and mass transfer modeling I： thermal treatment II : cryobiology • Micro and nano bio-heat and mass transfer I : modeling II : experimental techniques III: applications • Thermal physics in life sciences: tumor, energy and environment

10. References Papers: Modeling 1. Harry H. Pennes (1948) 2. Chen-Holmes (1980) 3. WJ Model (1984-85) 4. Baish (1994) 5. New vascular models (1997-2002) Thermoregulation and Physiology Advanced Thermal Measurement Techniques Latest Papers Related to Thermal Physics in Life Sciences Books: 1. Avraham Shitzer, Robert C. Eberhart, Heat Transfer in Medicine and Biology, 1985, Plenum Press, New York and London 2.Young I. Cho, Advances in Heat Transfer. Bioengineering Heat Transfer 1992, Academic Press, INC

11. Applications of Thermal Physics Cryosurgery of Prostate Cancer Protein and Gene Expression Alternated Thermal Treatment of Breast Cancer Thermally Targeted Nano Drug Delivery

12. Discussion • Bio-transport theories and experimental techniques for translational research (molecular diagnosis and treatment, nano-carrier delivery, tissue engineering etc.) • New comprehensive text book integrating bio-thermal physics, biomechanics, biochemistry, and advanced measurement techniques