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Use and production of radionuclide platinum-195m for nuclear medicine

Technology and Equipment Development for Photonuclear Production of Medical Radionuclides. Use and production of radionuclide platinum-195m for nuclear medicine. 197 Au(g,np) 195m Pt. Converter. Au-target. e -. g. RF linac. Energy 30-60 MeV Beam power 10-20 kW !!!!. Water.

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Use and production of radionuclide platinum-195m for nuclear medicine

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  1. Technology and Equipment Development for Photonuclear Production of Medical Radionuclides Use and production of radionuclide platinum-195m for nuclear medicine 197Au(g,np)195mPt Converter Au-target e- g RF linac Energy 30-60 MeV Beam power 10-20 kW !!!! Water

  2. Technology and Equipment Development for Photonuclear Production of Medical Radionuclides NSC KIPT1991-2011 KUT-30 W up to 35 MeV P up to 20 kW

  3. Technology and Equipment Development for Photonuclear Production of Medical Radionuclides NSC KIPT, Ukraine

  4. Technology and Equipment Development for Photonuclear Production of Medical Radionuclides Electron beam Converter Target capsule

  5. Technology and Equipment Development for Photonuclear Production of Medical Radionuclides The 195mPt obtain in reaction 197Au(,np)195mPt (T1/2=4.02 days). The 195mPt decay is accompanied by -radiation of nuclear transactions, X-rays and electrons of internal conversion. The Auger-MXY electrons have energy 2.417 keV and its abundance is 3.22 per 195mPt decay. The LET of this Auger electrons are 9.5 keV/m and the range 0.25 m. Therefore for incorporate cisplatin molecule the range of Auger electrons will be within the size of cell nucleus. The biological efficiency of electrons will be 100-300 times higher than in the case of malignant tumor irradiation by the external irradiation with the use of isotopes having significantly higher energies of particles (-radiation, electrons). Сisplatin penetrate into cell nucleus during treatment of cancerogenic illnesses.

  6. Technology and Equipment Development for Photonuclear Production of Medical Radionuclides Synthesis of radioactive cisplatin The dry precipitate H2[PtCl6]6 H2O was subjected to treatment with boiling water and was evaporated again on the water bath. Then the fresh 25% solution of potassium chloride was added to the tenfold-water solution of platinum hydrochloric acid up to the complete precipitation. H2[PtCl6] + 2KCl = H2[PtCl6] + 2HCl The yellow crystalline precipitation was obtained. After cooling the precipitate was washed during 1.5-2 hours with the diluted potassium chloride solution and alcohol. The obtained precipitate in the 6-7 fold quantity of water was slowly heated to boiling. In the process, as the quantity was small, water was added to the required volume. A 5% excess of lemon salt (0.39 g K2C2O4Н2Она 1 g K2[PtCl6]) was added to the boiling mixture. H2[PtCl6] + K2C2O4 = K2[PtCl4] + 2KCl + 2CO2 After boiling during 1 hour the red-crimson precipitate was formed. The obtained solution of potassium chloroplatinite K2[PtCl4] with addition of a necessary quantity of 20% solution of ammonium acetate (CH3COONH4) and potassium chloride was boiled during 1.5 hours with water replenishment. After cooling the precipitate of Pejrone salt of canary color was precipitated. K2[PtCl4] + 2CH3COONH4 = (NH3Cl)2Pt + 2CH3COOK + 2HCl 18.01.2011 6

  7. Technology and Equipment Development for Photonuclear Production of Medical Radionuclides The effect of initial and radioactive cisplatin with a high specific activity (~1Ci/mg) on the suspension of Ehrlich adenocarcinoma cells was investigated. Effect of high-active cisplatin on the Ehrlich cells, 120 min, 0.017 picograms

  8. Technology and Equipment Development for Photonuclear Production of Medical Radionuclides Action of initial and radioactive cisplatin on the Ehrlich adenocarcinoma cell viability NSC KIPT develops a photonuclear method of production of medical isotopes (99mTc, 67Cu, 103Pd etc.). After installation of hot cell we can deliver 195mPt isotope. Also we can carry out joint researches for further use radioactive cisplatin in nuclear medicine. 18.01.2011 8

  9. Technology and Equipment Development for Photonuclear Production of Medical Radionuclides We investigated influence of radioactive cisplatin on a tumour of mice. Percentage of the solid Ehrlich tumor growth inhibition after injection of initial and radioactive cisplatin was 35% and 65% respectively. White outbred mice with Ehrlich solid carcinoma under testing the action of initial and radioactive cisplatin 18.01.2011 9

  10. Technology and Equipment Development for Photonuclear Production of Medical Radionuclides Cytotoxicity patterns of various metal oxides ZnO nanoparticles are used as the selective cytotoxic agent for destruction of cancer cells. We investigate cytotoxic effect of synergetic influence of ZnO nanoparticlesand radioactive Zn Auger electrons upon normal and malignant cells. 18.01.2011 10

  11. Technology and Equipment Development for Photonuclear Production of Medical Radionuclides Thank you for attention 18.01.2011 11

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