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Hepatitis-2015 Orlando, USA July 20 - 22 2015. Parveen Malhotra. Epidemiological Profile Of Patients At a New Hub Of Hepatitis C in India. Dr. PARVEEN MALHOTRA MD,DNB (GASTRO),MNAMS,FIACM,FICP,PGDD PROFESSOR & HEAD DEPTT. OF MEDICAL GASTROENTEROLOGY PGIMS, ROHTAK.
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Hepatitis-2015Orlando, USAJuly 20 - 22 2015 Parveen Malhotra
Epidemiological Profile Of Patients At a New Hub Of Hepatitis C in India Dr. PARVEEN MALHOTRA MD,DNB (GASTRO),MNAMS,FIACM,FICP,PGDD PROFESSOR & HEAD DEPTT. OF MEDICAL GASTROENTEROLOGY PGIMS, ROHTAK
Sources of Infection for Persons with Hepatitis C Sexual 15% Transfusion 10% (before screening) *Nosocomial; Health-care work; Perinatal Other* 5% Injecting drug use 60% Unknown 10% Source: Centers for Disease Control and Prevention Source: Sentinel Counties, CDC
Indian Scenario • Nearly 12.5 million Indians are suffering from Hepatitis C affecting the liver. • Over one lakh people get infected every year in India, according to the Indian National Association for the Study of Liver (INASL) study. • Every 15th carrier of the HCV is an Indian, according to a recent report and it is responsible for as many as one in four cases of liver cancer and chronic liver disease.
HARYANA SCENARIO • Initially in Haryana , the prevalence of Chronic hepatitis C was thought to be comparable to other parts of India. • Now the prevalence has drastically increased and is reaching the levels of areas with high incidence like Manipur and Punjab. • There are certain districts like Jind , Kaithal, Fatehabad, Panipat, Karnal and Sonepat where Prevalence is touching even 40-50%.
GOOD NEWS FOR HARYANA • Haryana has become the first state of India where a separate, dedicated centre has been started under Department of Medical Gastroenterology, PGIMS, Rohtak. • Free treatment of Chronic Hepatitis C has been started for patients belonging to BPL/SC and at subsidized rates for general population. • Twenty thousand patients have been screened over different parts of haryana.
Patients were treated with standard doses of Pegylated Interferon and Ribavarin. • Up till now 1500 patients have completed treatment. • At present 1500 more patients are currently on treatment.
SOFOSBUVIR- A NEW HOPE • Up till now 200 patients have been put on treatment • Majority are on Triple therapy • Dual therapy – Decompensated cirrhotic or on patient will • RVR has been achieved in 95% of patients • Excellent Compliance rate
CONCLUSIONS • Haryana has become new hub of Chronic hepatitis C in India. • Majority of patients are male and belong to young age group i.e. 20-40 years of age group. • Genotype 3 most common and Genotype 4 is more common in comparison to other parts of Northern India. • Most common side effects- A.N. & Depression, Dyspepsia, Weight loss, Malaise, Generalized weakness. • Good compliance and success rates are being achieved.
TAKE HOME MESSAGE • Most important and first step is appreciation of problem. • Next step is to prioritize resources in more prevalent areas. • Development of Vaccine and Interferon free regimen is future dream for hepatitis C. • Regular Screening camps and awareness in society is utmost need of hour to curb the menace of this disease. • Do not wait till all resources are compiled- Start moving.
RATIONALE BASED TREATMENT • Pseudo belief on Alternative Medicines. • Anti HCV Vs HCV RNA based
ECONOMICAL TREATMENT STRATEGIES • SCIENTIFIC AND RATIONALE BASED TREATMENT • ROLE OF TREATING PHYSICIANS • ROLE OF STATE AND CENTER • ROLE OF NGO’S • ROLE OF PHARMACEUTICAL COMPANIES • ROLE OF MEDIA AND GENERAL POPULATION
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