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肿瘤乏氧显像概述 2

肿瘤乏氧显像概述 2. 山东省肿瘤医院 杨国仁. 乏氧显像剂－非硝基咪唑类. HL-91 Cu-ATSM. HL-91. HL-91. HL-91. HL-91 SPECT OF NSCLC. HL-91 SPECT OF NSCLC. HL-91 SPECT OF NSCLC. HL-91 SPECT OF NSCLC. Cu ATSM PET OF NSCLC. Cu ATSM PET OF NSCLC. 乏氧显像的机理 - 硝基咪唑类.

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肿瘤乏氧显像概述 2

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  1. 肿瘤乏氧显像概述2 山东省肿瘤医院 杨国仁

  2. 乏氧显像剂－非硝基咪唑类 • HL-91 • Cu-ATSM

  3. HL-91

  4. HL-91

  5. HL-91

  6. HL-91 SPECT OF NSCLC

  7. HL-91 SPECT OF NSCLC

  8. HL-91 SPECT OF NSCLC

  9. HL-91 SPECT OF NSCLC

  10. Cu ATSM PET OF NSCLC

  11. Cu ATSM PET OF NSCLC

  12. 乏氧显像的机理-硝基咪唑类 • 硝基咪唑类化合物通过弥散进入细胞内，其进入细胞内的能力决定于配体的亲脂性。一旦进入到存活细胞内后，在细胞内酶（主要是黄嘌呤氧化酶）的作用下发生单电子还原，产生自由基阴离子； • 在正常细胞中，由于氧化硝基有很高的电子亲和力，自由基阴离子有被迅速再氧化为原化合物，扩散到细胞外； • 当缺乏足够的氧时，自由基阴离子被进一步还原，产物与细胞内组分结合，滞留于细胞内。这类化合物的脂溶性和氧化还原电位是影响其乏氧显像能力的两个因素。

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