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Boceprevir in Treatment Experienced RESPOND-2

Phase 3. Treatment Experienced. Boceprevir in Treatment Experienced RESPOND-2. Bacon BR, et al. N Engl J Med. 2011;364:1207-17. Boceprevir for Retreatment of HCV Genotype 1 Infection RESPOND-2 Trial: Study Design.

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Boceprevir in Treatment Experienced RESPOND-2

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  1. Phase 3 TreatmentExperienced Boceprevir in Treatment ExperiencedRESPOND-2 Bacon BR, et al. N Engl J Med. 2011;364:1207-17.

  2. Boceprevir for Retreatment of HCV Genotype 1 Infection RESPOND-2 Trial: Study Design Drug DosingBoceprevir = 800 mg three times dailyPeginterferon alfa-2b = 1.5 µg/kg once weeklyRibavirin = 600-1400 mg/day (based on weight) Source: Bacon BR, et al. N Engl J Med. 2011;364:1207-17.

  3. Boceprevir for Retreatment of HCV Genotype 1 Infection RESPOND-2 Trial: Treatment Regimens Week 0 4 8 12 24 36 48 ✔ ✔ Lead In HCV RNA PR48 Placebo Peginterferon + Ribavirin Undetectable HCV RNA at week 8&12 Stop Therapy B32 PR36-48 Boceprevir Peginterferon + Ribavirin Detectable HCV RNA at week 8, but Undetectable at week 12 Peginterferon + Ribavirin Boceprevir B44PR48 Peginterferon + Ribavirin Source: Bacon BR, et al. N Engl J Med. 2011;364:1207-17.

  4. Boceprevir for Retreatment of HCV Genotype 1 Infection RESPOND-2 Trial: Results RESPOND-2: SVR 24 by Prior Response and Regimen 17/80 95/162 107/161 15/51 72/105 77/103 23/57 30/58 2/29 *Prior Nonresponse = decrease in HCV RNA of at least 2 logs by week 12, but detectable HCV RNA level during therapy period SVR = Sustained Virologic Response; B = Boceprevir; PR = Peginterferon+ Ribavirin Source: Bacon BR, et al. N Engl J Med. 2011;364:1207-17.

  5. Boceprevir for Retreatment of HCV Genotype 1 Infection RESPOND-2 Trial: Results Based on Initial Week 4 Response RESPOND-2: SVR 24, by Initial Response and Regimen 0/12 15/46 15/44 17/67 80/110 90/114 *Poor Initial Response to PR = decrease in HCV RNA level < 1 log10 IU/ml after 4 week lead in ^Good Initial Response to PR = decrease in HCV RNA level >1 log10 IU/ml after 4 week lead in SVR = Sustained Virologic Response; B = Boceprevir; PR = Peginterferon + Ribavirin Source: Bacon BR, et al. N Engl J Med. 2011;364:1207-17.

  6. Boceprevir for Retreatment of HCV Genotype 1 Infection RESPOND-2 Trial: Conclusions Source: Bacon BR, et al. N Engl J Med. 2011;364:1207-17.

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