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European Journal of Clinical Nutrition 2011; 65:386-393. Brooke Beasley and Ruth Sullivan

Differential Effects of Walnuts vs Almonds on Improving Metabolic and Endocrine Parameters in PCOS . European Journal of Clinical Nutrition 2011; 65:386-393. Brooke Beasley and Ruth Sullivan. Polycystic Ovary Syndrome. Signs and Symptoms Menstrual irregularities Infertility

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European Journal of Clinical Nutrition 2011; 65:386-393. Brooke Beasley and Ruth Sullivan

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  1. Differential Effects of Walnuts vs Almonds on Improving Metabolic and Endocrine Parameters in PCOS European Journal of Clinical Nutrition 2011; 65:386-393. Brooke Beasley and Ruth Sullivan

  2. Polycystic Ovary Syndrome • Signs and Symptoms • Menstrual irregularities • Infertility • Masculinizing hormones - acne and hirsutism • Fluid-filled ovarian cysts • Metabolic Syndrome • Insulin resistance • Dyslipidemia • Increased inflammation

  3. Study Objective & Methods • Compare the impact of • MUFA in almonds to • PUFA in Walnuts • On metabolic and endocrine components of PCOS • Randomized prospective study • 31 women participated • Individual packets of nuts containing 31 g of fat • 46 grams almonds • 36 grams walnuts daily • 6 weeks

  4. Data Collected • Anthropometric • Weight • Height • Sugar • Insulin • OGTT • HgbA1C • Dyslipedemia • Total Cholesterol • HDL • TG • Leptin • Adiponectin • Inflammatory Markers • CRP • TNF • IL • Masculinizing Hormones • Total testosterone • Sex hormone binding globulin (SHBG) • Free Androgen Index (FAI)

  5. Significant Findings • Walnuts reduced HgbA1C levels • PUFAs stimulated insulin secretion • Both walnuts and almonds increased adiponectin • helps control insulin sensitivity • Both decreased circulating androgen levels • Walnuts increased SHBG • Almonds decreased FAI

  6. Strengths and Weaknesses • Strength • Well controlled re: compliance of nut intake • Collected unused portions • Weakness • Small sample size: 31 individuals • No control group with PCOS without nuts

  7. Database Research on PCOS The Natural Standard database: • PCOS Treatment: • Promote normal weight status • High intake of fruits, vegetables, whole grains • No estrogen-rich food sources (tomatoes, nonorganic red meat/dairy) • Low carb • High carb weight gain estrogen stored in fat cells • High estrogen promotes ovarian cysts *No reference regarding fat quantity/quality http://www.naturalstandard.com/databases/conditions/condition-pcos.asp

  8. Database Research on Metabolic Syndrome The Natural Standard Database News, December 2008: “Eating a Mediterranean diet rich in nuts may help reverse Metabolic Syndrome.” http://www.naturalstandard.com/news/news200812017.asp

  9. Our Treatment Strategy for PCOS Promote optimal body weight Low glycemic/anti-inflammatory diet Organic animal proteins MUFA and n-3 PUFA rich food sources (nuts) Liver support (cruciferous vegetables) Decrease phytoestrogens (soy) & caffeine Spearmint tea for hirsutism Reduce stress/toxic environmental exposure

  10. In Conclusion A general anti-inflammatory or Mediterranean diet including MUFA and PUFA rich almonds and walnuts appears to be helpful in managing metabolic and endocrine symptoms in PCOS.

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