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Chronic Lung Disease Interventions. N. Singhal University of Calgary November 2006. Outline. Process Interventions proposed Infection – K. Aziz CLD – N. Singhal Interventions implemented Infection – K. Aziz CLD – N. Singhal Future directions – K. Aziz. Review Process . Cochrane reviews
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Chronic Lung DiseaseInterventions N. SinghalUniversity of CalgaryNovember 2006
Outline • Process • Interventions proposed • Infection – K. Aziz • CLD – N. Singhal • Interventions implemented • Infection – K. Aziz • CLD – N. Singhal • Future directions – K. Aziz
Review Process • Cochrane reviews • Systematic reviews • Informal reviews
CLD Group Interventions • Process • Experts selected topics • Training provided for literature review • Each centre given ONE topic to review
Review Process • Cochrane reviews • Systematic reviews • Informal reviews
Process cont’d • Meeting of all centre/experts to discuss areas for improvement • Generated list of interventions
Interventions Proposed • Antenatal • Treat urea plasma with erythromycin • Antenatal steroids
Interventions Proposed • Resuscitation • Early within one hour prophylactic surfactant <28 weeks or <1250 g. • Diminish hand ventilation • Decrease 100% oxygen exposure
Interventions Proposed • CPAP • Early CPAP for babies in supplemental oxygen • Long term CPAP
Interventions Proposed • Ventilation • Early use of HFV
Interventions Proposed • Normocarbia • Avoid hypocarbia • PaC02 40-55 mm of Hg
Interventions Proposed • Saturation targets • Saturation targets • > 88 to < 94 ? 93
Interventions Proposed • Nutrition/Fluids • Calories • Decrease fluid use • High dose Vitamin A
Interventions Proposed • Environment • Pain • Massage • Noise • NIDCAP
CLD Interventions Implemented • Antenatal: -Antibiotics -Expectant arrangement of PROM -Antenatal steroids
CLD Interventions Implemented • Resuscitation • Surfactant within 30 minutes • Avoid hand ventilation • Ventilation delivery room • Only Laerdel bags with PEEP • Blended gases
CLD Interventions Implemented • Ventilation • Early HVF – not done • Assist control and volume guarantee • Not done specifically
CLD Interventions Implemented • Normocarbia • PaC02 – 45-55 mm of Hg
CLD Interventions Implemented • Saturation targets • Sat alarm limits 85-95% • Goal 88-92% • Physician orders oxygen as drug
CLD Interventions Implemented • Nutrition/Fluids • ↓ TFI < 32 weeks first few days • TPN within 24 hours • TPN within 4 hours
CLD Interventions Implemented • Environment • Renovations to unit • ↓ sound levels
CLD Interventions Implemented • Others: • Comment card for parents • Avoid re-intubation with CPAP • Perinatal referral policies
> 27 weeks and < 34 weeks Extubate to CPAP if FiO2 <.4 (no time frame) Intubate, BLES Intubate, BLES transfer to NICU (*may be given in NICU after transfer) Extubate to CPAP if FiO2 <.4 at 2 to 4 hours of age and if clinically stable Stabilize then transfer to NICU Early CPAP – EPIC PDSA Cycle # 4 Respiratory Distress? (based on clinical judgment) Yes No Develops respiratory distress? No Routine management*** Yes Routine management*** Routine management*** If > 27 weeks, had HMD and on supplemental FiO2 in first 24 hours of life should be on CPAP *** wean from CPAP as per clinical indications