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Interferon Gamma Release Assays IGRAs for the Diagnosis of TB: Can We Replace the TST

Overview. Diagnosis of active and latent TBIn-Vitro Interferon Gamma Release Assays (IGRAs)Sensitivity and specificity of IGRAsImplementation data from San Francisco and Long Beach. Definitions.

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Interferon Gamma Release Assays IGRAs for the Diagnosis of TB: Can We Replace the TST

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    1. Interferon Gamma Release Assays (IGRAs) for the Diagnosis of TB: Can We Replace the TST? Helene M. Calvet, MD Health Officer and TB Controller Long Beach Department of Health and Human Services

    2. Overview Diagnosis of active and latent TB In-Vitro Interferon Gamma Release Assays (IGRAs) Sensitivity and specificity of IGRAs Implementation data from San Francisco and Long Beach

    3. Definitions “Positive PPD”: a tuberculin skin test (TST) that is indurated: >5 mm: HIV+, recent contact of TB case, CXR c/w old TB, organ transplant or other immunosuppression >10 mm: everybody else (in California) Latent TB Infection (LTBI): TB infection without evidence of clinically active disease (+PPD, but no symptoms); CXR usually normal, or may be abnormal, but sputa negative TB Disease: active tuberculous infection of any organ

    4. Diagnosis of TB TB disease Latent TB infection (LTBI)

    5. Toolbox for Diagnosis of TB Disease

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