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Telomeres in aging Universal STELA – a method to measure telomeres

Telomeres in aging Universal STELA – a method to measure telomeres. Laila Bendix, MD. VELUX FONDEN. Why do we age so differently?. Funded by:. Telomeres - structure. Telomeres - function . Shorten with cell aging. Differentiating from DSB. End replication problem.

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Telomeres in aging Universal STELA – a method to measure telomeres

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  1. Telomeres in agingUniversal STELA – a method to measure telomeres Laila Bendix, MD VELUX FONDEN Why do we age so differently? Funded by:

  2. Telomeres - structure

  3. Telomeres - function • Shorten with cell aging • Differentiating from DSB • End replication problem Harley et al 1990, Nature

  4. Telomeres relate to human aging Halaschek-Wiener et al 2008 Kimura et al 2008

  5. Do telomeres also shorten abruptly 12 kb 8 kb 4 kb 1.6 kb Signal free ends 0.6 kb Very short telomeres Graakjaer et al, Aging Cell 2004 0.1 kb Baird et al, Nat Genet 2003

  6. Abrupt shortening - mechanisms Passos et al 2007, NAR Ferenac et al, 2005; J Gerontol A Biol Sci Med Sci

  7. Overskrift Tekst Punkt 1 Punkt 2 Underpunkt 1

  8. Universal STELA – assay principles

  9. Telomeres – Project part I Short telomeres in organismal aging Does the number of short telomeres predict mortality even better? Number of short telomeres and DNA repair DNA repair functional studies Mitochondrial function Snp´s

  10. Telomeres and social class What do we think telomere length is an age-related parameter that remains aberrant after many years, and therefore is a suitable marker for social stress during life. What do we know Individuals of lower socio-economic status have shorter telomeres than their peers of a higher socio-economic status. Cherkas et al, 2006 No association between socio-economic status and telomere length. Adams et al, 2007 What do we have CAMB, MONICA and DARC Newer and better (?) methods

  11. Telomeres – Project part II Establish a high throughput method to measure telomeres Measure telomere lengths on samples collected in the CAMB study … and later Examine other aging related molecular biomarkers on same samples Short telomeres and social class

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