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The Influence of a High Fat Diet on the Lipoprotein Levels of Inbred Mice

The Influence of a High Fat Diet on the Lipoprotein Levels of Inbred Mice. By: Destiny Sanchez Efren Miranda Mirna Rocha. What is QTL?. QTL (Quantitative Trait Loci) are the locations on chromosomes where the genes that influence quantitative traits reside. (Robert J. Brooker ). QTL.

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The Influence of a High Fat Diet on the Lipoprotein Levels of Inbred Mice

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  1. The Influence of a High Fat Diet on the Lipoprotein Levels of Inbred Mice By: Destiny Sanchez Efren Miranda Mirna Rocha

  2. What is QTL? • QTL (Quantitative Trait Loci) are the locations on chromosomes where the genes that influence quantitative traits reside. (Robert J. Brooker) QTL • A Quantitative Trait is a trait of a gene that can be described with numbers. Phenotype

  3. Key Terms • HDL Cholesterol (High Density Lipoproteins) • LDL Cholesterol (Low Density Lipoproteins) • Atherosclerosis

  4. Heart Attack and Stroke • Heart attacks and Stroke are a result of atherosclerosis • A build up of fat around arterial walls will eventually lead to complete arterial blockage • Could result in death

  5. Purpose • To perform QTL analysis on inbred mice in order to determine the effects of a high fat diet on HDL concentrations and Atherosclerosis susceptibility.

  6. Test Subjects C57BL/6J (B6) X 129S1/SvImJ(129) B6x129 (F1) F2 Progeny

  7. Method • Fed high diet to 294 (F2) female mice for 14 weeks • Measured plasma HDL concentrations • Measured size of aortic fatty-streak lesions • Performed QTL analysis

  8. Data

  9. Data

  10. HDL Effect Plot

  11. Results • 129 mice had high HDL levels and Atherosclerosis resistance • B6 mice displayed low HDL and High Atherosclerosis susceptibility • F2 intercross - 6 Loci for HDL were identified and 5 loci for heart disease susceptibility

  12. Conclusion • A high fat diet plays a large role in the damaging of the aortic system leading to heart disease. • The QTL for traits are located on the same regions of the chromosomes in mice and humans.

  13. Increase Your HDL High fiber diet Vegetables Low Fat Lean Protein

  14. References • Brooker, Robert J.. Genetics Analysis and Principles. New York, NY: McGraw-Hill, 2009. • http://beckerinfo.net/bioinformatics/?p=1118

  15. Thank You! Dr. Randy Von Smith Tobias Beckwith Dr. Brook Milligan RISE Program

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