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FLUID MOSAIC MODEL

FLUID MOSAIC MODEL. FLUID MOSAIC MODEL. Model describing structure of the cell membrane Model says cell membrane is not solid, fluid. Has the consistency of olive oil. FUNCTIONS OF PLASMA MEMBRANE. FUNCTIONS OF PLASMA MEMBRANE.

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FLUID MOSAIC MODEL

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  1. FLUID MOSAIC MODEL

  2. FLUID MOSAIC MODEL • Model describing structure of the cell membrane • Model says cell membrane is not solid, fluid. • Has the consistency of olive oil

  3. FUNCTIONS OF PLASMA MEMBRANE

  4. FUNCTIONS OF PLASMA MEMBRANE • Protective barrier - contains cytoplasm (contents of the cell)

  5. FUNCTIONS OF PLASMA MEMBRANE Transport Regulates movement of substances in / out of cell (selectively permeable)

  6. FUNCTIONS OF PLASMA MEMBRANE Cell recognition Allows cells to identify surrounding cells http://www.dailymail.co.uk/sciencetech/article-491062/Multicoloured-brainbow-shows-nerve-activity.html

  7. FUNCTIONS OF PLASMA MEMBRANE Cellular Attachment Cell membranes have junctions – surfaces which interlock keeps cells together – and surfaces which attach them to the extra cellular matrix.

  8. FUNCTIONS OF PLASMA MEMBRANE Signal Transduction converts a mechanical/chemical stimulus to a cell into a specific cellular response.

  9. FUNCTIONS OF PLASMA MEMBRANE Enzyme Activity Cells rely on thousands of different enzymes to catalyze metabolic reactions, many of these occur at the cell membrane. http://www.nature.com/scitable/topicpage/protein-function-14123348

  10. STRUCTURE OF PLASMA MEMBRANE

  11. MEMBRANE COMPONENTS • Proteins (intergral & peripheral) • Carbohydrates (glucose) • Phospholipids • Cholesterol

  12. PHOSPHOLIPIDS • Make up 30-70% of the cell membrane • Phospholipids are like triglycerides with a phosphate • Come together to make a fluid membrane

  13. PHOSPHOLIPID ORIENTATION • In water, phospholipids form a bilayer • A cell membrane is a bilayer

  14. PHOSPHOLIPID ORIENTATION • Liposome is a small vesicle, with an aqueous compartment surrounded by a bilayer

  15. PHOSPHOLIPID ORIENTATION PHOSPHATE HEADS – are water loving and point toward water FATTY ACID TAILS – are water fearing and orient themselves to each other

  16. PHOSPHATE HEAD – HYDROPHYLIC FATTY ACID TAILS – HYDROPHOBIC

  17. CLOSER LOOK OF THE PLASMA MEMBRANE

  18. PROTEINS

  19. INTEGRAL PROTEINS • Proteins surrounded by phospholipids which go through the membrane • Functions: serve as ion channels, membrane pumps, or receptors

  20. FLUID MOSAIC MODEL

  21. INTEGRAL PROTEINS

  22. PERIPHERAL PROTEINS • Proteins which attach to the membrane • Predominately interact with integral proteins • Can attach by weak hydrogen bonds 1. interaction by an amphipathicα-helix parallel to the membrane plane (in-plane membrane helix) 2. interaction by a hydrophobic loop 3. interaction by a covalently bound membrane lipid (lipidation) 4. electrostatic or ionic interactions with membrane lipids (e.g.through a calcium ion)

  23. PERIPHERAL PROTEINS

  24. GLYCOPROTEINS • GLYCOPROTEINS found on the surface of the membrane • Serve as recognition sites for chemicals • Involved in cell to cell interactions

  25. GLYCOLIPIDS • Between phospholipids • Face extracellular fluid and serve as “cell identifiers”

  26. CHOLESTEROL • Involved in keeping membrane “fluid”

  27. GLYCOLIPIDS

  28. REVIEW

  29. http://bio-animations.blogspot.ca/2008/04/plasma-membrance-fluid-mosaic-model.htmlhttp://bio-animations.blogspot.ca/2008/04/plasma-membrance-fluid-mosaic-model.html

  30. References • Original presentation by M.Bregar (Dante C.S.S.) http://www.authorstream.com/Presentation/aSGuest77986-711145-fluid-mosaic-model/ • Modified by D. Machacek

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