1 / 6

R Tuli MD PhD, JP Christodouleas MD MPH, L Roberts, SJ Deol, DA Frassica MD,

Method of Detection of Ipsilateral Breast Tumor Recurrence Following Breast Conserving Therapy is a Predictor of Distant Metastases. R Tuli MD PhD, JP Christodouleas MD MPH, L Roberts, SJ Deol, DA Frassica MD, RC Zellars MD, KY Usuki MD, KL Brill MD, AL Rosenberg MD. Background.

tessa
Download Presentation

R Tuli MD PhD, JP Christodouleas MD MPH, L Roberts, SJ Deol, DA Frassica MD,

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Method of Detection of Ipsilateral Breast Tumor Recurrence Following Breast Conserving Therapy is a Predictor of Distant Metastases R Tuli MD PhD, JP Christodouleas MD MPH, L Roberts, SJ Deol, DA Frassica MD, RC Zellars MD, KY Usuki MD, KL Brill MD, AL Rosenberg MD

  2. Background • Current clinical guidelines suggest the method of detection (clinical vs. radiographic) of ipsilateral breast tumor recurrence (IBTR) following breast conserving therapy (BCT) does not influence survival • Controversy exists regarding the optimal surveillance of such patients Purpose • We attempt to determine the prognostic significance of method of detection of IBTR on distant metastases (DM)-free survival Author Disclosures: None

  3. Methods • IRB approved, retrospective single institution chart review of all newly diagnosed breast cancer patients • Treated with BCT between 1981 and 2007 • We identified patients who subsequently developed IBTR • Charts reviewed for: • Demographics • Clinical presentation • Method of detection • Stage • Type of therapy • Histopathology • Margin status (primary and recurrent tumors) • All patients presenting with DM following BCT or a suspected new primary with different histology following BCT were excluded

  4. Results • Median follow-up from time of recurrence 27 months (1 to 231) • Median time from IBTR to DM was 151 months • 5-year DM-free survival following IBTR was 69.5%

  5. Results • Univariate analysis of pt/tumor characteristics on DM-free survival

  6. Results • Median DM-free survival for clinically and radiographically detected IBTRs was 54 months and > 231 months (median was not reached), respectively • On multivariate Cox regression analysis, clinically detected IBTRs remained a significant predictor of lower DM-free survival • Adjusted relative risk for clinically detected IBTRs was 2.2 Conclusions • Contrary to previous reports, clinical detection of local recurrence remains a significant risk factor for time to DM • In contrast, radiographic detection of such recurrences confers a higher DM-free survival • These results support the necessity for regular and timely radiographic evaluations following IBTR in patients previously treated with BCT

More Related