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SNPs in Coding Regions – No Changes in Protein

SNPs in Coding Regions – No Changes in Protein. G A C. G A G. DNA SNP C to G. mRNA. CUG. CUC. RNA Codon CUG to CUC. C U G. C U C. Protein Leucine to Leucine. Leucine. Leucine. No change in shape. SNPs in Coding Regions – Subtle, Harmless Changes in Protein. C T A. C T C.

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SNPs in Coding Regions – No Changes in Protein

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  1. SNPs in Coding Regions – No Changes in Protein G A C G A G DNA SNP C to G mRNA CUG CUC RNA CodonCUG to CUC C U G C U C Protein Leucine to Leucine Leucine Leucine No change in shape

  2. SNPs in Coding Regions – Subtle, Harmless Changes in Protein C T A C T C DNA SNP A to C mRNA GAU GAG RNA CodonGAU to GAG G A U G A G Protein Aspartic acid to Glutamic acid Aspartic acid Glutamic acid Slight change in shape

  3. SNPs in Coding Regions – Harmful Changes in Protein – Mutations DNA SNP T to A C T A C A A mRNA GAU GUU RNA CodonGAU to GUU G A U G U U Protein Aspartic acid to Valine Valine Aspartic acid Change in shape

  4. SNPs in Coding Regions – Subtle Changes in Proteins That Only Switch on Under Certain Conditions Smoking Switched-on genes Pattern A Many years later Pattern B Many years later = SNPs causing latent effects

  5. Smoking and Susceptibility to Lung Cancer Activator Precarcinogen Carcinogen Water-SolubleCarcinogen Eliminator

  6. Smoking and Susceptibility to Lung Cancer – SNPs in Carcinogen-Making Proteins Hyperactive Activator Lazy Activator Precarcinogen Precarcinogen Carcinogen Carcinogen

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