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Memory Consolidation

Memory Consolidation. Trace Reactivation. Slow wave Sleep. Memory Consolidation. At the time of encoding, memories are susceptible to disruption. With time, they become robust to interference (Mueller and Pilzecker, 1900) Cerebral trauma leads to a greater loss

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Memory Consolidation

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  1. Memory Consolidation Trace Reactivation Slow wave Sleep

  2. Memory Consolidation At the time of encoding, memories are susceptible to disruption. With time, they become robust to interference (Mueller and Pilzecker, 1900) Cerebral trauma leads to a greater loss of recent than remote memories (Ribot, 1882)

  3. SLEEP Non-REM REM Stages 1 2 3 4 Spindles Slow wave,delta

  4. Slow-wave sleep (~1-4Hz) contains: Slow oscillation(~1Hz) (a.k.a up/down states) Faster rhythms can be embedded in the up phase of the up state The ‘up’ state is named for intracellular depolarization…notice how this appears as a trough in the extracellular LFP or in the EEG signal Neuroscience 137 (2006) 1087–1106 GROUPING OF BRAIN RHYTHMS IN CORTICOTHALAMIC SYSTEMS. M. STERIADE* Laboratory of Neurophysiology, Laval University, Faculty of Medicine,

  5. Is there evidence for trace replay theory? Memory Trace Reactivation … when neural activity patterns seen during a task are ‘replayed’ during subsequent periods of inactivity

  6. Memory Trace Reactivation Key Studies • In rats, hippocampal activity patterns during behavior are related to patterns during subsequent periods of inactivity(Pavlides and Winson, 1989; Wilson and McNaughton, 1994), • specifically, in hippocampal oscillations (Kudrimoti et al., 1999) • demonstrated to co-occur with slow-waves (Sirota et al., 2003; Battaglia et al., 2004) • seen in the hippocampus and neocortex of rats (Qin et al., 1997; Ribeiro et al., 2004; Ji and Wilson, 2007)

  7. Memory Consolidation Causal Trace Reactivation Slow wave Sleep

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