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Panax Notoginseng , San Qi Anti Hyperglycemic, Anti-Obesity Study

Panax Notoginseng , San Qi Anti Hyperglycemic, Anti-Obesity Study. Korrin Fotheringham Sarah Altvater Mikaela Hew. What is Panax Notoginseng ?. One of the varieties of Ginseng family of herbs “Ginseng” refers to several species of the genus “ Panax ”- cure all

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Panax Notoginseng , San Qi Anti Hyperglycemic, Anti-Obesity Study

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  1. PanaxNotoginseng, San QiAnti Hyperglycemic, Anti-Obesity Study KorrinFotheringhamSarah AltvaterMikaela Hew

  2. What is PanaxNotoginseng? • One of the varieties of Ginseng family of herbs • “Ginseng” refers to several species of the genus “Panax”- cure all • For more than 2,000 years- Chinese Medicine • Perennial plant with flowers that grows to about 1.2 m high at a slow rate. Can grow in full or partial and requires moist soil.

  3. Dosage/Toxicity Many herbs and supplements have not been thoroughly tested, and safety and effectiveness have not be proven. (Brands can have variable ingredients) Recommended after using ginseng continuously for 2-3 weeks, take 1-2 week break Long-term dosing should not exceed 1 gram of dry root daily. Adults (over 18):Capsules 100-200 mg of ginseng extract by mouth once or twice daily for up to 12 weeks. Dry ginseng root 0.5-2 grams of, taken daily by mouth Dry extract 300 mg daily used for 8 weeks to improve quality of life in elderly patients. Fluid 1-2 grams added to 150 ml of water, taken by mouth daily. Fluid extract 1:1 (g/ml) taken as 1-2 ml by mouth daily. about 1-2 tspof a 1:5 (g/ml) taken by mouth daily. Panax ginseng tea may be made by soaking about 3,000 mg of chopped fresh root or 1,500 mg dried root powder in about 5 oz of boiling water for 5-15 minutes and then strain

  4. Purpose of Study • Does Panax Notoginseng Saponins (PNS) affect fasting blood glucose levels (FBGL), glucose tolerance (GT), insulin levels, leptin levels, body weight, food intake? • Test previous studies, mechanisms underlying anti-hyperglycemic and anti-obese effects • Explore individual effective anti-diabetic components in PNS

  5. Materials/Method • PanaxNotoginsengfrom Wenshan • Previously studied • Root sample obtained and authenticity ensured • Ground and filtered to extract PNS • Saponins: Rb1(29.86%), Rg1(20.46%), Rd(7.96%), Re(6.83%), and R1(2.74%) • High performance liquid chromatography (HPLC) • Extracts gained and frozen before use • Dissolved in vehicle for intraperitoneal administration

  6. Experimental setup • 10 week old mice • C57BL/6J positive control • KK-Ay with high FBGL = Syndrome X • Vehicle – daily at 10ml/kg • PNS – daily at 200mg/kg • Saponin – daily, differing amounts • proportional to concentration in PNS

  7. Blood collection • FBGL measured from tail blood samples • IPGT test • End of the study • Blood samples collected for serum insulin, leptin, triglyceride (TG), cholesterol (CH) levels • Epididymal fat pads weighed

  8. Results • FBGL levels shown • All KK-Ay have high FBGL baseline • Day 12: PNS and Rb1 significant decrease • Re tendency to reduce • Day 30: PNS further decreased PNS Rb1 PNS Re

  9. Results • IPGT test results • Day 0: KK-Ay glucose intolerance and hyperglycemic • Day 30: PNS 40% decrease • Significant decrease in other areas a well

  10. Discussion PNS • Hypoglycemic effect • Improved insulin sensitivity and glucose homeostasis • Enhanced leptin sensitivity • Anti-obesity effect • Reduced serum triglycerides Saponin constituents • Reduction of FBGL from Rb1 • Hypoglycemic effect in vivo • Decreasing trend of FBGL from Re • Single use of any had no anti-obese activity

  11. Areas for Future Research • Therapeutic benefits of Ginseng: • PNS and adiponectin • Serum leptin levels and leptin resistance • Ginseng from different origins • Effects of varying dosage • Different saponin combinations

  12. Limitations • Male mice • Small sample size (6 mice per group) • Source of saponins • Dosage timing • Length of study • What are the long term effects? • Does the effect level off at some point? • Are the side effects?

  13. Our Personal Opinion

  14. References • http://www.mayoclinic.com/health/ginseng/NS_patient-ginseng

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