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This table lists the genes that are upregulated in Panc-1 and CFPAC-1 cells when exposed to PAUF. The genes include DACH2, KCNJ2, ELAVL4, SPRED1, PGAP1, WWC3, TFPI2, CXCR4, ADCYAP1R1, FOXP2, ROR1, SLC2A3, SORBS2, EXT1, EDNRB, IL1RL1, FLJ23861, FHL1, ZNF403, GJA10, MAP3K8, PDE4DIP, SEC24D, WIPF1, LY96, CPM, GJA10, and many more.
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Supplementary Table 1. List of upregulated genes by PAUF * Probe ID Gene Symbol Gene Title Panc-1PAUF CFPAC-1 shPAUF 239738_at DACH2 dachshund homolog 2 (Drosophila) 48.9 -14.2 206765_at KCNJ2 potassium inwardly-rectifying channel, subfamily J, member 2 35.2 -3.0 234904_x_at ELAVL4 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D) 26.9 -47.2 233465_at SPRED1 sprouty-related, EVH1 domain containing 1 13.7 -19.3 233479_at PGAP1 GPI deacylase 12.5 -2.4 225273_at WWC3 WWC family member 3 11.6 -2.2 209277_at TFPI2 tissue factor pathway inhibitor 2 10.5 -2.4 217028_at CXCR4 chemokine (C-X-C motif) receptor 4 10.2 -5.6 226690_at ADCYAP1R1 adenylate cyclase activating polypeptide 1 (pituitary) receptor type I 9.5 -2.8 227383_at no information CDNA FLJ36837 fis, clone ASTRO2011422 9.5 -2.1 1555516_at FOXP2 forkhead box P2 9.1 -13.7 231142_at ROR1 receptor tyrosine kinase-like orphan receptor 1 8.6 -2.6 209278_s_at TFPI2 tissue factor pathway inhibitor 2 7.5 -2.0 202499_s_at SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 7.2 -4.5 233720_at SORBS2 sorbin and SH3 domain containing 2 7.0 -2.1 1557647_a_at no information CDNA FLJ34880 fis, clone NT2NE2015885 6.9 -3.2 219427_at FAT4 FAT tumor suppressor homolog 4 (Drosophila) 6.8 -2.2 1562863_at EXT1 exostoses (multiple) 1 6.1 -5.7 204271_s_at EDNRB endothelin receptor type B 6.0 -2.2 234066_at IL1RL1 interleukin 1 receptor-like 1 5.4 -3.5 1558595_at FLJ23861 hypothetical protein FLJ23861 5.3 -3.6 201539_s_at FHL1 four and a half LIM domains 1 5.0 -3.0 233937_at ZNF403 zinc finger protein 403 4.8 -2.4 227769_at no information Transcribed locus, strongly similar to NP_061844.1 G protein-coupled receptor 27;super conserved receptor expressed in brain 1 [Homo sapiens] 4.2 -4.9 231969_at STOX2 storkhead box 2 4.1 -4.3 1556777_a_at no information Full length insert cDNA YN57B01 4.0 -3.6 237634_at C1QTNF3 C1q and tumor necrosis factor related protein 3 4.0 -12.9 242724_x_at NR6A1 nuclear receptor subfamily 6, group A, member 1 3.9 -2.7 206462_s_at NTRK3 neurotrophic tyrosine kinase, receptor, type 3 3.9 -8.3 237794_at LOC554226 hypothetical protein LOC554226 3.9 -19.0
Supplementary Table 1 - continued Probe ID Gene Symbol Gene Title Panc-1PAUF CFPAC-1 shPAUF 206100_at CPM carboxypeptidase M 3.9 -8.1 221415_s_at GJA10 gap junction protein, alpha 10, 59kDa 3.8 -15.4 235421_at MAP3K8 mitogen-activated protein kinase kinase kinase 8 3.8 -2.7 232615_at PDE4DIP phosphodiesterase 4D interacting protein (myomegalin) 3.8 -2.2 215209_at SEC24D SEC24 related gene family, member D (S. cerevisiae) 3.7 -2.9 235706_at CPM carboxypeptidase M 3.5 -2.7 202664_at WIPF1 WAS/WASL interacting protein family, member 1 3.4 -4.3 206584_at LY96 lymphocyte antigen 96 3.4 -2.0 231513_at no information Transcribed locus 3.3 -3.9 240482_at HDAC3 histone deacetylase 3 3.3 -2.6 231165_at DDHD1 DDHD domain containing 1 3.3 -26.8 244286_at FNBP1 formin binding protein 1 3.3 -3.7 219520_s_at WWC3 WWC family member 3 3.3 -2.1 207143_at CDK6 cyclin-dependent kinase 6 3.2 -2.2 232113_at LOC399959 hypothetical gene supported by BX647608 3.2 -2.2 211429_s_at SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 3.2 -3.1 1564378_a_at EXT1 exostoses (multiple) 1 3.2 -31.5 239146_at CLDND1 claudin domain containing 1 3.2 -2.4 243054_at ZMYND11 zinc finger, MYND domain containing 11 3.1 -2.1 202665_s_at WIPF1 WAS/WASL interacting protein family, member 1 3.0 -2.2 231240_at DIO2 deiodinase, iodothyronine, type II 3.0 -3.2 234137_s_at RANBP17 RAN binding protein 17 2.9 -3.9 204530_s_at TOX thymus high mobility group box protein TOX 2.8 -3.2 224901_at SCD5 stearoyl-CoA desaturase 5 2.8 -2.2 224848_at CDK6 cyclin-dependent kinase 6 2.8 -2.3 200906_s_at PALLD palladin, cytoskeletal associated protein 2.7 -2.0 233364_s_at LOC399959 hypothetical gene supported by BX647608 2.6 -8.2 220484_at MCOLN3 mucolipin 3 2.6 -3.6 215318_at CG012 hypothetical gene CG012 2.6 -3.1 234082_at no information no information 2.6 -3.6 242913_at CLIC6 chloride intracellular channel 6 2.6 -3.0 1557252_at HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 2.6 -9.0 219906_at FLJ10213 hypothetical protein FLJ10213 2.5 -4.3 241240_at ATF6 activating transcription factor 6 2.5 -3.6
Supplementary Table 1 - continued Probe ID Gene Symbol Gene Title Panc-1PAUF CFPAC-1 shPAUF 1557419_a_at ACSL4 acyl-CoA synthetase long-chain family member 4 2.5 -4.1 231145_at PAX9 paired box gene 9 2.5 -8.6 242986_at NAV1 neuron navigator 1 2.4 -3.1 232797_at ITGAV integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) 2.4 -3.5 211551_at EGFR epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) 2.4 -2.2 237346_at TGDS TDP-glucose 4,6-dehydratase 2.4 -9.3 1556282_at FGFR1OP2 FGFR1 oncogene partner 2 2.4 -2.5 1569325_at ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa 2.3 -3.5 235102_x_at GRAP GRB2-related adaptor protein 2.3 -8.7 235176_at ZNF545 zinc finger protein 545 2.3 -3.6 237189_at no information Transcribed locus, strongly similar to NP_002137.3 homeo box B3;homeo box 2G;homeobox protein Hox-B3 [Homo sapiens] 2.3 -3.8 1569961_at no information Homo sapiens, clone IMAGE:2960615, mRNA 2.3 -2.1 238137_at PLRG1 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) 2.3 -4.6 1554131_at KIAA1128 KIAA1128 2.3 -3.0 243673_at RBM41 RNA binding motif protein 41 2.3 -3.3 1569490_at FNDC3B fibronectin type III domain containing 3B 2.2 -2.7 210004_at OLR1 oxidized low density lipoprotein (lectin-like) receptor 1 2.2 -3.2 244755_at no information no information 2.2 -4.1 41856_at no information Full-length cDNA clone CL0BB018ZE07 of Neuroblastoma of Homo sapiens (human) 2.2 -2.2 1565974_at SUV420H1 suppressor of variegation 4-20 homolog 1 (Drosophila) 2.2 -2.6 210680_s_at MASP1 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) 2.2 -2.7 1558732_at no information no information 2.1 -3.5 236288_at RNF34 ring finger protein 34 2.1 -2.3 235756_at SAMD4A sterile alpha motif domain containing 4A 2.1 -2.7 207234_at RFX3 regulatory factor X, 3 (influences HLA class II expression) 2.1 -7.4 208039_at no information no information 2.1 -3.0 238757_at DBF4B DBF4 homolog B (S. cerevisiae) 2.1 -2.3 234704_at no information no information 2.1 -7.8 224405_at FCRL5 Fc receptor-like 5 2.1 -32.6 222141_at KLHL22 kelch-like 22 (Drosophila) 2.1 -2.1
Supplementary Table 1 - continued Probe ID Gene Symbol Gene Title Panc-1PAUF CFPAC-1 shPAUF 241769_at ITGAV integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) 2.1 -2.9 206157_at PTX3 pentraxin-related gene, rapidly induced by IL-1 beta 2.1 -2.8 230672_at no information CDNA clone IMAGE:4841343 2.1 -2.2 1557018_a_at no information CDNA clone IMAGE:5312582 2.0 -4.5 240365_at LOC647946 hypothetical protein LOC647946 2.0 -2.0 1562960_at LOC338653 hypothetical protein LOC338653 2.0 -8.9 204567_s_at ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1 2.0 -3.9 202637_s_at ICAM1 intercellular adhesion molecule 1 (CD54), human rhinovirus receptor 2.0 -2.8 221155_x_at no information PRO1496 2.0 -2.7 228632_at no information CDNA FLJ37243 fis, clone BRAMY2004387 2.0 -2.9 *List of 96 genes (104 fragments) expressed at levels more than two-fold higher in Panc-1_PAUF than in Panc-1_Mock and more than twofold lower in CFPAC-1_shPAUF than in CFPAC-1_shCtrl.
