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Lactase genes and evolution. Points of concern. Lactase and curriculum General Biology course General Microbiology Genetics What is the problem? Students misconceptions. Data set. 86. resources.
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Points of concern • Lactase and curriculum • General Biology course • General Microbiology • Genetics • What is the problem? • Students misconceptions
Data set 86
resources • See images.ppt and .doc files for visual database of organisms from which sequences were obtained • Sequence files (.doc) are organized by type of organism and lactase subunit
Sample Questions: Level 1 • Is the bacterial lactase gene similar to the human lactase gene? • Is this gene exclusive to eukaryotic or to prokaryotic organisms? • How is this gene distributed across the organisms?
Sample Questions: Level 2 • How does the bacterial lactase gene compare to archaebacteria? • What evolution scheme can be inferred? • Describe the evolutionary relationships within and among the different groups of organisms.
Splt Decomposition (ESTEEM module) to determine relationships between four plants based on lactase sequence
References • Genoscope Centre national de séquençage • http://www.genoscope.cns.fr/externe/English/corps_anglais.html • BRENDA: The Comprehensive Enzyme Information System • http://www.brenda.uni-koeln.de/index.php4 • Genomics: GLT, Systems Biology for Energy and Environment • http://genomicsgtl.energy.gov/links/archaea.shtml • Genomes News Network • http://www.genomenewsnetwork.org/categories/index/genome.php?s=0&n=15 • Doe Joint Genome Institute http://www.jgi.doe.gov/ • Fungal Cell Biology Group http://129.215.156.68/index.htmlBaNG: Nematodes and Neglected Genomicshttp://zeldia.cap.ed.ac.uk/index.shtml • iHOP- Information Hyperlinked over proteins http://www.ihop-net.org/UniPub/iHOP/ • European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI) http://www.ebi.ac.uk/clustalw/ • National Center for Biotechnology Information http://www.ncbi.nlm.nih.gov/ • Biology Workbench http://workbench.sdsc.edu/