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Results of the ACCORD Glycemia Trial on Mortality and the Primary Outcomes

The results of the ACCORD Glycemia Trial presented at the ADA 68th Scientific Sessions in 2008 show the effect of intensive glycemia intervention on mortality rates. The trial's safety measures, outcomes, and participant follow-up are detailed, highlighting the switch to standard glycemia goals. The data indicates an increase in mortality for those targeting A1C <6% compared to 7.0-7.9%. Ongoing analyses aim to provide deeper insights.

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Results of the ACCORD Glycemia Trial on Mortality and the Primary Outcomes

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  1. Results of the ACCORD Glycemia Trial on Mortality and the Primary Outcomes Presented at the American Diabetes Association 68th Scientific Sessions on June 10, 2008.

  2. Participant Followup

  3. Median A1C and Interquartile Ranges

  4. Adverse Events *Motor Vehicle Accident

  5. Stopping the Glycemia Comparison • 10 member DSMB reviewed interim results every 6 mo. • Monitored primary outcome, mortality rates and other variables to assure safety of participants • Recommended discontinuing the intensive glycemia intervention on January 8, 2008 after reviewing mortality trends for several months; this was accepted by NHLBI • ACCORD participants were informed on February 5 and switched to standard glycemia group goals • Results presented here are based on data available to the DSMB at their meeting in January

  6. All Cause Mortality 1.41%/yr 1.14%/yr HR = 1.22 (1.01-1.46) P = 0.04

  7. Primary & Secondary Outcomes

  8. Cause of Death

  9. Cause of Death, continued

  10. All Cause Mortality 1.41%/yr 1.14%/yr HR = 1.22 (1.01-1.46) P = 0.04

  11. Hazard Ratios for Total Mortality by Subgroup

  12. Primary & Secondary Outcomes

  13. Primary Outcome 2.29%/yr 2.11%/yr HR = 0.90(0.78-1.04) P = 0.16

  14. Hazard Ratios for Primary Outcome by Subgroup

  15. Conclusions • In people with type 2 diabetes at high risk for CVD, with an A1C of 7.5% or more, a therapeutic strategy that targets an A1C <6% vs. 7.0-7.9% increases mortality over 3.5 years • There is no significant effect of the glycemic intervention on the primary outcome at this time • Ongoing follow-up and ongoing analyses (both epidemiologic & within baseline subgroups) will add further insight and generate more hypotheses

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