C-MYC Signaling Pathway

1. C-MYC Signaling Pathway The MYC-family of cellular proto-oncogenes encode three highly related nuclear phosphoprotein, C-MYC, N-MYC and L-MYC. The genes corresponding to these three proteins are located on chromosome 8, chromosome 2 and chromosome 1, respectively. The structure of MYC includes the first exon that does not encode a protein, and the other is the third exon that encodes a protein. The MYC gene belongs to an oncogene encoding a nuclear protein that encodes a nuclear DNA binding protein involved in cell cycle regulation. The MYC gene family and its products promote cell proliferation, transformation. immortalization, dedifferentiation and The product of the C-MYC gene is the 62KD phosphorylated protein p62c-myc, which is located in the nucleus and is a nuclear protein consisting of 439 amino acids encoded by exons a and 3 of the c-myc gene. The C-MYC protein can be structurally divided into a transcriptional activation region, a non-specific DNA binding region, a nuclear target sequence, a basic region, a helix-loop-helix (HLH) and a leucine zipper region, among known transcription factors. It can mediate the oligomerization of proteins. The simultaneous presence of these two regions is unique to C-MYC protein. Among other proteins, it is rarely found. In C-MYC protein, the helix-ring-helix follows the alkaline the region reveals its interaction with DNA in a specific sequence. Studies in prokaryotes have shown that the basic region exists as a free loop and becomes a helix when bound to DNA in a special way. This region is the binding site of C-MYC protein to DNA specific sequence. The native protein C-MYC is a bHLHLZ (basic region/helix-loop-helix/leucine zipper) transcription factor that combines with a specific electronic box to form consistent core sequence 5’-CACGTG-3’. https://www.creative-diagnostics.com/c-myc-signaling-pathway.htm