CD27/CD70 Signaling Pathway

1. CD27/CD70 Signaling Pathway CD27 and CD70 molecules are typical members of the tumor necrosis factor (TNF). So CD27 is also known as the tumor necrosis factor receptor superfamily 7(TNFRSF7), and its ligand is called tumor necrosis factor ligand superfamily 7(TNFLSF7). Similar to other TNFSF ligands, CD70 is expressed as a single spanning transmembrane protein with an extracelluar domain comprising a stalk region. Several ligands of the TNFSF molecules have been described that are naturally generated by proteolysis in the stalk region or by alternative splicing. The possible natural occurrence of CD70 forms has been poorly addressed so far but various recombinant variants of CD70 containing the THD have been investigated and found to be able to interact with CD27. In its N-terminal extracellular domain, CD27 contains two complete and one incomplete version of the cysteine rich domain (CRD), which is characteristic for the TNFRSF. These TNFRSFs can be divided into three categories: First, death receptors, which frequently induce apoptosis and whose intracellular domains contain a protein-protein interaction domain called death domain. Second, TNF receptor-associated factors (TRAF)-interacting receptors that interact by help of short peptide motifs with trimeric adapter proteins of the TRAF family and third, decoy receptors lack its own authentic signaling capabilities that act by regulating signal transduction of receptors of the two other groups of TNFRSF receptors. https://www.creative-diagnostics.com/cd27-cd70-signaling-pathway.htm