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flavivirus

flavivirus<br>

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flavivirus

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  1. Flavivirus The Flaviviradae is a large family of viral pathogens responsible for causing severe disease and mortality in humans and animals. The family consists of three genera: Flavivirus, Pestivirus and Hepacivirus. The Flavivirus genus, which is the largest of the three, contains more than 70 viruses including Dengue Virus (DV), Japanese Encephalitis Virus (JEV), West Nile Virus (WNV), Yellow Fever Virus (YFV) and Zika Virus (ZIKV). Flaviviruses show morphological uniformity with an icosahedral capsid and closefitting, spiked envelope. The size of the capsid is about 30 nm and the whole virion measures 45 nm. The genome of the flaviviruses is a singlestranded sense RNA about 10 kb in size. It codes for 3 structural proteins: capsid (C protein), membrane (M, which is expressed as prM, the precursor to M and envelope (E protein) and 7 nonstructural proteins: NS1, NS2A, NS2B, NS3, NS4A, NS4B and NS5 (Figure 1 a.b). http://www.creative-diagnostics.com/Flavivirus.htm

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