IL-17 Signaling Pathway

1. IL-17 Signaling Pathway Interleukin 17 (IL-17 or IL-17A) is a pro-inflammatory cytokine. This cytokine is generated by a group of T helper cell known as T helper 17 cells. Originally, Th17 was defined in 1993 by Rouvier et al. who isolated IL17 transcripts from rodent T-cell hybridomas. IL-17(A) is a 155-amino acid protein that is a disulfide-linked, homodimeric, secreted glycoprotein with a molecular mass of 35 kDa. Comparison of different members of the IL-17 family uncovers four conserved cysteines that form two disulfide bonds. IL-17 is unique in that it bears no resemblance to other known interleukins. The biologically active IL-17 interacts with type I cell surface receptor IL-17R. After binding to the receptor, IL-17 activates several signaling cascades that, in turn, result in the induction of chemokines. Acting as chemoattractant, these chemokines recruit the immune cells, such as monocytes and neutrophils to the site of inflammation. Typically, signaling events mentioned above follow an invasion of the body by pathogens. Promoting the inflammation, IL-17 acts in concert with tumor necrosis factor and interleukin-1. Moreover, the activation of IL-17 signalling is often observed in the pathogenesis of various autoimmune disorders, such as psoriasis. https://www.creative-diagnostics.com/il-17-signaling-pathway.htm