KLF4 Signaling Pathway

1. KLF4 Signaling Pathway The kruppel-like factors (KLFs) family are zinc finger protein transcription factors, which are important protein in the body and participate in the regulation of cell proliferation, differentiation, embryo development and other important life processes, in cell differentiation and it plays a key role in cell cycle arrest. Kruppel-like factor 4 (KLF4; gut-enriched kruppel-like factor or GKLF) is a zinc-finger transcription factor, and it was first identified in 1996. KLF4 is a member of the KLF family of transcription factors, it is one of the most studied KLFs family members. KLF4 is widely expressed in the body, mainly expressed in the digestive tract, oral cavity, esophageal epithelium, skin epidermis, vascular endothelium and thymic epithelial cells. Among them, gastrointestinal epithelial cells express KLF4 most abundantly, so it is also called GKLF KLF4, also known as gut-enriched kruppel-like factor (GKLF). Which belongs to the relatively large family of SP-1like transcription factors. KLF4 is involved in the regulation of proliferation, differentiation, apoptosis and somatic cell reprogramming. Evidence also suggests that KLF4 is a tumor suppressor in certain cancers, including colorectal cancer. The human KLF4 gene is located on chromosome 9q31 and is a single-copy gene located in the minus strand, covering a 6.3 kb gene segment with five exons. Its encoded protein contains 513 amino acids with a molecular mass of approximately 55 kDa. Its cDNA coding region is 1413 bp in length and encodes a polypeptide consisting of 470 amino acid residues; however, the mouse KLF4 is located on chromosome 4B3, and the mouse KLF4 protein contains 483 amino acid residues in full length, 91% homology with the human KLF4 protein amino acid sequence, and 103 amino acid residues at the carboxy terminus. Analysis by RNA transfer blotting showed that human and mouse KLF4 transcripts were 3.5 kb in length and 53 kDa in relative molecular mass. But KLF4 is expressed higher in mouse tissues. https://www.creative-diagnostics.com/klf4-signaling-pathway.htm