Leptin Signaling Pathway

1. Leptin Signaling Pathway Leptin (LP) is a protein hormone secreted by adipose tissue. It has been widely believed that after entering the blood circulation, it will participate in the regulation of sugar, fat and energy metabolism, prompting the body to reduce food intake, increase energy release, inhibit the synthesis of fat cells, and thus reduce weight. Halaas et al. applied DNA recombination technology in 1995, and the expression product of the ob gene is synthesized from E. coli, and the protein is named as levels of human plasma leptin are directly proportional to body fat weight, and leptin and its receptor gene mutations can lead to morbid obesity. The function of leptin is multifaceted, mainly in the regulation of fat and body weight: appetite suppression: leptin can significantly reduce human feeding, body weight, and body fat content. Increase energy consumption: Leptin can act on the center to increase sympathetic nerve activity and convert a large amount of stored energy into heat energy release; leptin can directly inhibit fat synthesis and promote its decomposition, and some people think that leptin can promote fat cell maturation. In addition, insulin can promote the secretion of leptin, which in turn plays a negative feedback regulation on the synthesis and secretion of insulin. Leptin family Leptin is a protein hormone secreted by fat cells and is mainly produced by white fat. Brown fat, skeletal muscle, bone mucosa, placenta and fetal heart, bone, and soft bone tissue can also secrete. It consists of three exons and two introns with a mRNA length of 4.5 kb and an open reading frame capable of encoding 167 amino acids. Isse et al. cloned the human leptin gene, which is located on chromosome 7, has a full length of 20 kb, consists of three exons and two introns, and the 5' end contains multiple transcription factor junctions, which is a single copy gene. In cattle, the leptin gene is located on chromosome 4, which is also composed of three exons and two introns. Find more at: https://www.creative-diagnostics.com/leptin-signaling-pathway.htm