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Obesity individuals secrete less adiponectin than lean individuals. The decreased production of adiponectin, in combination with the inability of adipose tissue to store the surplus free fatty acids (FFAs), can be considered to reflect adipose tissue dysfunction. Under normal conditions, adiponectin increases insulin sensitivity directly, by stimulating tyrosine phosphorylation of the insulin receptor. <br>
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Obese Signaling Pathway Obesity means a person who's very overweight, at least 20% higher than it should be. It's a common problem in the US and worldwide. According to National Health and Nutrition Examination Survey (NHANES) data, it's estimated to affect around 30% adults and around 20% children aged 10 to 11. For children, rates of obesity have risen even faster. Obesity is the second cause of death in the world and has reached epidemic proportions in recent years. An Overview of Obesity Obesity and overweight involve an abnormal and excessive fat accumulation that negatively affects the health status. According to the World Health Organization (WHO), if body mass index (BMI) is equal or greater than 25 kg/m2, it is considered overweight, whereas the BMI higher than 30 kg/ m2 defines obesity (Figure 1). It stems from a positive mismatch between energy intake and energy expenditure. Western societies are “obesigenic” environments where people have become sedentary while food portions have grown “super-sized” and highly processed convenience foods and soft drinks provide a glut of calories throughout the day. https://www.creative-diagnostics.com/obese-signaling-pathway.htm