Pakinson disease pathway

1. Pakinson disease pathway Parkinson’s disease (PD) is a devastating disorder of the nervous system. It is typically characterized by motor deficits that are closely associated with progressive degeneration and loss of dopaminergic neurons in the substantia nigra and pars compacta, as well as subsequent reduction of dopamine levels in striatum. Additionally, executive dysfunction such as impulsivity and deficits in attention, short-term working memory, and speed of mental processing. With a global prevalence in millions, has been regarded as the second most common neurodegenerative disorder behind Alzheimer’s disease. However, no cure for PD is currently available, as the most commonly used therapies neither restore the lost or degenerated dopaminergic neurons, nor stop or delay the disease progression. PD is a multifactorial disorder, where both genetic and non-genetic, such as toxin exposure and environmental factors, are involved. There are quite a few theories as to the cellular and molecular mechanisms of PD initiation and progression, including mitochondrial damage, oxidative stress, excitotoxicity, protein misfolding and aggregation, failure of protein clearance pathways, neuroinflammation and cell-autonomous mechanisms. Find more: https://www.creative-diagnostics.com/parkinson-s-disease-pathway.htm