Resistin Signaling Pathway

1. Resistin Signaling Pathway Resistin is a cysteine-rich secreted protein present in plasma and belongs to resistin-like molecules (RELMs), also known as members of the family of FIZZs (found in inflammatory zone). Rodent resistin is secreted exclusively by adipocytes; whereas human resistin is expressed primarily in peripheral blood mononuclear cells and is increased in expression upon differentiation into macrophages. Recent studies have shown that resistin acts on insulin signaling pathways to induce insulin resistance, and acts on vascular endothelial cells and smooth muscle cells to affect cell function, suggesting that resistin may be involved in vascular lesions. Resistin family Resistin is rich in cysteine residues and consists of 108 amino acid residues with a full length of 476 base pairs. The relative molecular mass is 12.5×103. The gene coding region is located on chromosome 19p13. The resistin, anti-receptor-like molecules α (RELM-α), RELM-β, and RELM-γ belong to the RELMs family. The mouse has a high degree of homology with the human resistin gene fragment. Patel et al. first reported the general structure of resistin using X-ray crystallization technology and identified two different rat resistin cycle states: a lamanyh molecular mass (HMW) hexamers and low molecular mass monomer forms. The latter is considered to have a higher biological activity against hepatic insulin dysfunction in vivo. Several different high molecular mass subtypes have recently been demonstrated in human serum resistin. Different isomers have different biological activities in muscle and liver tissues, especially in obesity and insulin resistance models. Find more at: https://www.creative-diagnostics.com/resistin-signaling-pathway.htm