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TGFB SMAD Signaling Pathway

The TGF-β superfamily includes a diverse range of structurally and functionally related proteins, such as bone morphogenetic proteins (BMPs), activins, inhibins, growth differentiation factors (GDFs), and glial-derived neurotrophic factors (GDNFs). These members multifunctionally regulate a wide range of biological processes, such as morphogenesis, embryonic development, adult stem cell differentiation, immune regulation, wound healing, inflammation, and cancer.

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TGFB SMAD Signaling Pathway

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  1. TGFB SMAD Signaling Pathway The TGF-β superfamily includes a diverse range of structurally and functionally related proteins, such as bone morphogenetic proteins (BMPs), activins, inhibins, growth differentiation factors (GDFs), and glial-derived neurotrophic factors (GDNFs). These members multifunctionally regulate a wide range of biological processes, such as morphogenesis, embryonic development, adult stem cell differentiation, immune regulation, wound healing, inflammation, and cancer. These proteins signal by stimulating formation of specific heteromeric complexes of type I and type II serine/threonine kinase receptors. When bioavailable TGF-β reaches the surface of the target cell, it binds a homodimer of TGF-β type II receptors (TβRII). The TGF-β-TβRII complex provides a structural interface that facilitates stable complex formation with a homodimer of the TGF-β type I receptor (T βRI). As an active receptor complex, the TβRII, which is a constitutively active kinase, undergoes autophosphorylation, and catalyzes transphosphorylation of the T β RI. Transphosphorylation of the TβRI activates kinase activity. https://www.creative-diagnostics.com/tgf-b-smad-signaling-pathway.htm

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