Vaspin Signaling Pathway

1. Vaspin Signaling Pathway An overview of vaspin Adipose tissue is an energy storage organ and an important endocrine organ of the whole body. Adipose tissue mainly includes subcutaneous adipose tissue and visceral adipose tissue (VAT), which are not only involved in energy metabolism, but also have more active endocrine functions in secreting a wide variety of fat factors such as leptin, adiponectin, resistin and lactone. Vaspin (visceral adipose tissue-derived serine protease inhibitor) is a newly discovered adipokine in recent years. It transmits signals through vaspin and the above adipokines, adipose tissue and other tissues, and participates in the pathological and physiological processes of glycolipid metabolism, blood pressure, obesity, and apoptosis, for example, inflammatory reaction can affect the development of diabetes and atherosclerosis through multiple links. Therefore, the study of vaspin signaling pathway is particularly important for the treatment of related diseases. Vaspin family Vaspin is a member of the serine protease inhibitor family. When an animal model of spontaneous type 2 diabetes was established in OLETF (Otsu-ka Long-Evans Tokushima Fatty) rats, and the peak plasma concentration of obesity and insulin occurred, Hida et al found that vaspin was highly expressed in visceral adipose tissue. It was found to be a novel gene, ol-64, which shares 40% homology with α 1-antitrypsin. Studies have shown that vaspin is not only expressed in adipose tissue, but also expressed in different degrees in tissues such as skin, stomach, pancreas, liver and hypothalamus, suggesting that vaspin may exert its physiological effects on multiple target organs. The open reading frame of vaspin cDNA consists of 1245, 1236, and 1242 deoxynucleotides in human, rat, and mouse, respectively. The proteins contain 415, 412, and 414 amino acid residues, respectively. The human vaspin protein is a single peptide with a hydrophobic N-terminus with a relative molecular mass of 45200. https://www.creative-diagnostics.com/vaspin-signaling-pathway.htm