Warburg Effect Signaling Pathway

1. Warburg Effect Signaling Pathway Different from normal differentiated cells, which rely primarily on mitochondrial oxidative phosphorylation to generate the energy needed for cellular processes, cancer cells rewire their metabolism to promote growth, survival, proliferation, and long-term maintenance through aerobic glycolysis. The common feature of this altered metabolism is increased glucose uptake and fermentation of glucose to lactate. This phenomenon is observed even in the presence of completely functioning mitochondria and together is known as the Warburg Effect. The Warburg Effect has been documented for over 90 years. In the 1920s, Otto Warburg and colleagues observed that tumors were taking up enormous amounts of glucose compared to what was seen in the surrounding tissue. With extensively studied, this metabolism of glucose was then termed the Warburg Effect in the early 1970s, which is required for tumor growth. In tumors and other proliferating or developing cells, the rate of glucose uptake dramatically increases and lactate is produced, even in the presence of oxygen and fully functioning mitochondria. That means in order to kill tumor cells by depriving them of energy, both glucose and oxygen had to be eliminated. https://www.creative-diagnostics.com/warburg-effect-signaling-pathway.htm