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Identifying topics on TB treatment for literature review

Identifying topics on TB treatment for literature review. In collaboration with International Child Health Review Collaboration (ICHRC) Meeting of the Childhood TB Subgroup Paris, 1 November 2006 Shamim Qazi WHO, Geneva. Why do we need the evidence base?.

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Identifying topics on TB treatment for literature review

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  1. Identifying topics on TB treatment for literature review In collaboration with International Child Health Review Collaboration (ICHRC) Meeting of the Childhood TB Subgroup Paris, 1 November 2006 Shamim Qazi WHO, Geneva

  2. Why do we need the evidence base? • Evidence often not easily accessible • Helpful in the acceptance of guidelines in countries • Helpful in medical education and other pre-service training • Defines need for further research

  3. 7 alternatives to evidence-based medicine • Eminence • Vehemence • Eloquence • Providence • Diffidence • Nervousness • Confidence…. based medicine BMJ 319: 1618 (1999)

  4. Why PubMed? • Provides free access to Medline • 16 million citations • 4800 journals • 30-40 languages • OLDMEDLINE for pre-1966 citations. • Provides a Clinical Queries search filters page • Uses keywords or Medical Subject Headings (MeSH) • A spell checker

  5. Why PubMed? • Provides articles not yet indexed in Medline (in press) • Defined sensitivity and specificity • Can save and re-run searches using the “My NCBI” function • Combining filters with limits as well if needed • Request email updates as new trials/reviews are published

  6. Why Clinical queries? • provides specialized PubMed searches for clinicians • easier to find articles that report applied clinical research. • defined sensitivity and specificity • methodology validated by hand searching • Haynes et al; http://www.nlm.nih.gov/pubs/techbull/jf04/cq_info.html • ……again can save results and search strategies • Easy and quick!

  7. Clinical Queries using Research Methodology Filters

  8. ICHRC web site www.ichrc.org

  9. Reviewer's Tool kit

  10. Cough or difficult Breathing

  11. ARI Questions addressed • In children aged 2-59 months with pneumonia, which clinical signs best predict hypoxemia?What are the common causes of childhood pneumonia in developing countries? • Should zinc be used in the prevention and management of acute respiratory infections? • What is the most appropriate empirical therapy for very severe pneumonia in children older than 2 months? • What are the clinical risk factors for death in children with pneumonia? • Is 3 days of amoxicillin as effective as 5 days or more in the treatment of non-severe pneumonia in children? • What are appropriate empiric antibiotics for empyema? • What is the role of subcutaneous adrenaline in the management of acute asthma? • When are oral steroids indicated in acute asthma?

  12. Possible Paediatric TB Areas for review • Epidemiology • Diagnosis • Treatment • Contact tracing and management • Programme monitoring and evaluation • Health staff and family roles and responsibilities • BCG immunization

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