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CHAPTER 14

CHAPTER 14. DISEASES OF WHITE BLOOD CELLS LYMPH NODES SPLEEN THYMUS. Diseases of WBCs, Lymph Nodes, Spleen, Thymus. WBCs and Lymph Nodes Spleen Thymus. WBC’s and LYMPH NODES. NORMAL PATHOLOGY. PATHOLOGY. Leukopenia Reactive (Inflammatory) Proliferations of WBCs and Lymph Nodes

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CHAPTER 14

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  1. CHAPTER 14 DISEASES OF WHITE BLOOD CELLS LYMPH NODES SPLEEN THYMUS

  2. Diseases of WBCs, Lymph Nodes, Spleen, Thymus • WBCs and Lymph Nodes • Spleen • Thymus

  3. WBC’s and LYMPH NODES • NORMAL • PATHOLOGY

  4. PATHOLOGY • Leukopenia • Reactive (Inflammatory) Proliferations of WBCs and Lymph Nodes • Neoplastic Proliferations of WBCs

  5. LEUKOPENIA • Neutropenia, Agranulocytosis • Pathogenesis • Morphology • Clinical Course

  6. REACTIVE (Inflammatory) Proliferations of WBCs and Lymph Nodes • Leukocytosis • Lymphadenitis, Acute • Lymphadenitis, Chronic

  7. LEUKOCYTOSIS

  8. ACUTE Lymphadenitis

  9. CHRONIC Lymphadenitis • Follicular Hyperplasia • Paracortical Hyperplasia • Reticular Hyperplasia (Sinus Histiocytosis)

  10. NEOPLASTIC Proliferations of WBCs and Lymph Nodes • Etiology • Lymphoid • Myeloid • Histiocytosis

  11. Etiology/PathogenesisFactors • Chromosomes • Oncogenes • Viruses • Environmental • Iatrogenic

  12. LYMPHOID • Definitions • Classifications • B, T • Good , Medium, Bad • Follicular, Diffuse • Hodgkins vs. NON-Hodgkins

  13. LYMPHOID • ACUTE Lymphoblastic Leukemia/Lymphoma (ALL) • CHRONIC Lymphocytic Leukemia/Lymphoma (CLL/SLL)

  14. LYMPHOID • FOLLICULAR Lymphoma • DIFFUSE Lymphoma (Large B-Cell)

  15. LYMPHOID • Burkitt Lymphoma

  16. LYMPHOID • Plasma Cell Neoplasms • Multiple Myeloma • Solitary Myeloma • Monoclonal Gammopathy of Unknown Significance (MGUS)

  17. MULTIPLE MYELOMA

  18. LYMPHOID • Lymphoplasmacytic Lymphoma

  19. LYMPHOID • Mantle Cell Lymphoma • Marginal Zone Lymphoma

  20. LYMPHOID • Hairy Cell Leukemia • Peripheral T-Cell and NK-Cell Neoplasms • Peripheral T-Cell Lymphoma • Anaplastic Large Cell Lymphoma

  21. LYMPHOID • Adult T-Cell Leukemia/Lymphoma • Mycosis Fungoides/Sézary Syndrome • Large Granular Lymphocytic Leukemia • Extranodal NK/T-Cell Lymphoma

  22. LYMPHOID • HODKIN LYMPHOMA • Classification • RS (Reed-Sternberg) Cell Criteria • Histologic Prognostic Features • Etiology • Pathogenesis • Clinical Course • Morphology

  23. Nodular Sclerosis

  24. Mixed Cellularity

  25. Lymphocyte-Rich

  26. Lymphocyte Depletion

  27. Lymphocyte Predominance

  28. MYELOID • AML (Acute Myelogenous Leukemia) • Myelodysplastic Syndromes • Chronic Myeloproliferative Disorders • CML (Chronic Myelogenous Leukemia) • PV (Polycythemis Vera) • Essential Thrombocytosis • Primary Myelofibrosis

  29. AML • Etiology • Pathogenesis • Classification • Morphology • Immunophenotype • Chromosome • Clinical Features • Prognosis

  30. “Myelodysplastic”Syndromes • Classification • Morphology • Clinical Course

  31. Chronic Myeloproliferative Disorders

  32. CML • Etiology • Pathogenesis • Morphology • Clinical Features

  33. P. Vera • Etiology • Pathogenesis • Morphology • Clinical Course

  34. EssentialThrombocytosis

  35. Primary Myelofibrosis • Etiology • Pathogenesis • Morphology • Clinical Course

  36. Langerhans Cell Histiocytosis

  37. SPLEEN • Normal • Pathology

  38. PATHOLOGY • Splenomegaly • Neoplasms • Congenital Anomalies • Infarcts • Rupture

  39. Splenomegaly • Acute Splenitis • “Congestive” Splenomegaly • Infiltrative Disorders

  40. SPLEEN • Neoplasms

  41. SPLEEN • Congenital

  42. SPLEEN • Rupture

  43. THYMUS • Normal • Pathology

  44. PATHOLOGY • Developmental Disorders • Hyperplasia • Thymomas

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