1 / 5

Effect of Vasodilator Therapy on Mortality in Chronic Congestive Heart Failure Results of a Veterans Administration Coop

Effect of Vasodilator Therapy on Mortality in Chronic Congestive Heart Failure Results of a Veterans Administration Cooperative Study (V-HEFT I). Multicenter, randomized, double-blind, placebo-controlled trial 642 men followed for an average of 2.3 years Patient History:

tiara
Download Presentation

Effect of Vasodilator Therapy on Mortality in Chronic Congestive Heart Failure Results of a Veterans Administration Coop

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. Effect of Vasodilator Therapy on Mortality in Chronic Congestive Heart FailureResults of a Veterans Administration Cooperative Study (V-HEFT I) • Multicenter, randomized, double-blind, placebo-controlled trial • 642 men followed for an average of 2.3 years • Patient History: • Men with impaired cardiac function and reduced exercise tolerance • All patients were taking digoxin and diuretics • In addition to mortality, the follow-up data included EF, exercise tolerance and echocardiography N Engl J Med 1986;314:1547-52

  2. V-HEFT IObjectives • To evaluate the effects of vasodilator therapy on mortality among patients with chronic congestive heart failure, impaired cardiac function and reduced exercise tolerance who were taking digoxin and diuretics • Patients were randomized to double-blind treatment with placebo, prazosin (20 mg per day), or the combination of hydralazine (300 mg per day) and isosorbide dinitrate (160 mg per day) N Engl J Med 1986;314:1547-52

  3. V-HEFT ICumulative Mortality from the Time of Randomization in the Three Treatment Groups N Engl J Med 1986;314:1547-52

  4. V-HEFT IResults • Mortality over the entire follow-up period was lower in the Hyd-Iso group vs. placebo. The difference was of borderline statistical significance • Risk reduction at two years in the Hyd-Iso group was 34% (p=0.028) • Risk reduction at three years in the Hyd-Iso group was 36% • Mortality in the prazosin group was similar to placebo • EF rose significantly at eight weeks and at one year in the Hyd-Iso group but not in the placebo or prazosin groups. N Engl J Med 1986;314:1547-52

  5. V-HEFT IConclusion • “The data suggests that the addition of hydralazine and isosorbide nitrate to the therapeutic regimen of digoxin and diuretics in patients with chronic congestive heart failure can have a favorable effect on left ventricular function and mortality” N Engl J Med 1986;314:1547-52

More Related