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Most of us Jeremy. Coding DNA. --------T G G ------ --------T G T ------. Template DNA. --------A C C ------ --------A C A ------. Messenger RNA. --------U G G ------ --------U G U ------. Amino Acid.
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Most of us Jeremy Coding DNA --------T G G ------ --------T G T ------ Template DNA --------A C C ------ --------A C A ------ Messenger RNA --------U G G ------ --------U G U ------ Amino Acid --------TRYPTOPHAN------ --------CYSTEINE ------ These guys also carry mutations…apparently
--------T G T ------ -----T G G ---- With point mutation G to Tie a substitution X Man Jeremy Most of us ISO ISO The offending amino acid LEU LEU ALA ALA CYS TRY ASP ASP ISO ISO PRO PRO Blimmin X Men everywhere
What would be the result if the mutation was a substitution of the G to a C ? -----T G G ----- Most of us ISO ISO Don’t forget to go: …coding DNA …template DNA…mRNA…A A LEU LEU ALA ALA ? TRY ? ASP ? ISO ? PRO
Original With MUTATION TGG TGC Coding DNA Template DNA ACG ACC mRNA UGG UGC Cys Try Amino Acid What the…That is the same as Jeremy How come? There are 64 codons and 20 amino acids, that’s how come
The answer... X Man Jeremy Most of us ISO ISO LEU LEU ALA ALA CYS TRY ASP ASP ISO ISO PRO PRO So no change then !!! -----T G c------ will still give CYS
What would be the result if the mutation was a substitution of the G to an A ? -----T G G ------ Most of us ISO ISO LEU LEU ALA ALA ? TRY ? ASP ? ISO ? PRO
The answer... Most of us ISO ISO LEU LEU ALA ALA STOP! TRY ASP A non-sense mutation.It will make a very short proteinMost likely with no function ISO PRO