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Introduction

Introduction. FACILITATING TRANSLATIONAL RESEARCH AND MEDICINE INSTITUTE FOR CANCER/STEM CELL BIOLOGY AND MEDICINE. Stanford School of Medicine Leadership Retreat January 30 - February 1, 2003. Principal Goals.

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Introduction

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  1. Introduction FACILITATING TRANSLATIONAL RESEARCH AND MEDICINE INSTITUTE FOR CANCER/STEM CELL BIOLOGY AND MEDICINE Stanford School of Medicine Leadership Retreat January 30 - February 1, 2003

  2. Principal Goals • Broaden and help integrate basic research in stem cell biology and cancer biology. • Initiate and Expand translational research in Cancer/Stem Cell Biology and Medicine. • Support (or establish) clinical trials derived from Institute’s translational research. • Pursue an organizational structure to accomplish these goals. • NCI-designated Cancer Center; either a • Fully integrated Comprehensive Cancer Center, or a • Research Cancer Center

  3. Current Areas of Research Interests Critical advances in research and medicine in last 10-15 years. • Hematopoietic Stem and Progenitor Cells and Transplantation • Other Adult Tissue or Organ Stem Cells • Stem Cell and Progenitor Cell Gene Expression Pathways: Self-Renewal • Cancer Stem Cells • Pluripotent Stem Cells • Nuclear Transplantation to Produce Pluripotent Stem Cells: Nuclear Reprogramming

  4. Research Collaborations Current Stem/Cancer Cell Collaborations: • Developmental Biology (Scott, Fuller, Nusse and Kim) • Biochemistry (Spudich) • Ob/Gyn (Husain, Polan and Teng) • Neurology (Mobley) • Neurosurgery (Tse, Skirbol and Palmer) • Medicine/BMT (Shizuru, Negrin and JWBrown) • Pathology (Cleary;van der Rijn and Galli) • MCP (Nelson) • Urology (Shortliffe,pending) • Interdepartmental Mouse Gene Array Program (PBrown, Barsh, et al.) • Residents and MD Fellows from Pediatrics, Hematology, Pathology and Oncology.

  5. Teaching Programs • Interface with departmental and IDP graduate programs in: • Cancer Biology, Immunology, Development Biology, Neurosciences, Neurobiology, etc. • MSTP and future Stem Cell/Cancer Biology Scholarly Concentration for medical students.

  6. Faculty • Small number of Associates • Collaborative searches for Associate Faculty • Search: Deputy Director for Scientific Programs (Cancer Biology) • Search: Pluripotent Stem Cell Biologist • Deputy Director for Clinical Programs: Karl Blume • Large number of Affiliates • Located in departments • Access to “hotel” space in Institutes

  7. Expectations Unique roles of Institute in Translational Research and Medicine: • All appointments of faculty associates only in basic to translational fields in cancer or stem cell biology • Affiliates have opportunity to apply for 2-3 year bench in Institute, selected by Steering Committee and Directorate • Specialized facilities in Institute available to Associates and Affiliates • Spearhead development of a NCI Cancer Center • Organize course and Medical Scholar track, including research and clinical training • In the future, if legal and feasible, provide human pluripotent stem cell lines derived from defined disease nuclei to Stanford investigators

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