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Stem Cell Regulation: Bmi1, Senescence, and Self-Renewal

Explore the role of Bmi1 in stem cell self-renewal and senescence regulation in this lab seminar. Learn about the properties of stem cells, including self-renewal and differentiation, as well as the mechanisms that regulate the stability of stem cell populations. Discover the potential of Bmi1 as a molecular target for inducing senescence in cancer stem cells. Future directions include investigating the expression of HERVs in stem cells and tumor cells.

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Stem Cell Regulation: Bmi1, Senescence, and Self-Renewal

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  1. The series of stem cellSeason Ⅱ Bmi1, stem cells, and senescence regulation 111회 lab seminar 발표자 신호수

  2. Stem cells possess three fundamental properties • They must self-renew, allowing the maintenance of the original stem cell population. • stem cells must be able to differentiate into multiple types of mature cells • Total number of stem cells is strictly regulated via both extrinsic and intrinsic mechanisms, resulting in the stability of a stable stem cell pool

  3. A stem cell is an unspecialized cell type

  4. Self renewal signal of HSC

  5. Stem cells and senescence ※ What is senescence? Senescence is a state in which a cell no longer has the ability to proliferate. ※ The Hypothesis of Cellular senescence 1. Histone deacetylase inhibitors, which decondense chromatin and activate the transcription of some genes induce a senescence-like state in human fibroblasts suggesting that conversion of some heterochromatin to euchromatin may be a feature of replicative senescence 2. Chromatin condensation and subsequent downregulation of certain genes might regulate senescence.

  6. Postulated Bmi1 targets. Extrinsic signals for a stem cell to self-renewresult in elevation of the Bmi1 level in stem cells.

  7. Role of Bmi1 in stem cell self-renewal

  8. Chart of major signaling pathways

  9. Bmi1 and senescence

  10. G1-S phase transition

  11. Future directions • Bmi1 could be used as a molecular target to induce senescence in cancer stem cells • Transplantation approch

  12. Our approach • Stem cells have similar properties with tumor cells • So What kind of HERVs are expressed in stem cells and tumor cells? • If HERVs are expressed , do they differ or ….? And so on…

  13. 111 Hit!! Thank U

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