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Interferons

Interferons. Type II IFN. IFN- a. IFN- b. IFN- e. IFN- k. IFN- t. IFN- d. IFN-ω. IFN- l1 ( IL -29). IFN- l2 ( IL -28 A ). IFN- l3 ( IL -28 B ). IFN- g. Type III IFN. Type I IFN. Reza Khorooshi Email: rkhorooshi@health.sdu.dk.

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Interferons

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  1. Interferons Type II IFN IFN-a IFN-b IFN-e IFN-k IFN-t IFN-d IFN-ω IFN-l1 (IL-29) IFN-l2 (IL-28A) IFN-l3 (IL-28B) IFN-g Type III IFN Type I IFN Reza KhorooshiEmail: rkhorooshi@health.sdu.dk

  2. Innate receptor-mediated induction of type I IFN Exogenous stimuli: Endogenous stimuli: LPS Molecules released upon tissue damage, immune complex Bacteria Virus dsDNA dsDNA CPG DNA dsRNA dsRNA ssRNA dsRNA TLR4 Cytoplasm Endosome P TLR3 TLR9 STING MDA5 RIG-I DAI TLR7/8 MyD88 MyD88 TBK1 IKK IRAK TRIF TRIF IRFs IRFs Type I IFN Type I IFN Type I IFN promoter Nucleus

  3. Interferon signaling Type I IFN Type II IFN Type III IFN Type II IFN IFNAR1 IFNAR2 IFNGR1 IFNGR2 IL10R-b IL28R-a Cytoplasm JAK1 JAK2 JAK1 TYK2 JAK1 TYK2 STAT2 STAT1 P STAT1 P P P P P STAT1 STAT1 STAT1 STAT1 STAT2 STAT1 IRF9 MX, 2,5-OAS, PKR IRFs CXCL10 RIG-I MHC SOCS others ISGF3 Nucleus ISGs ISRE GAS

  4. Type I IFN function Type I IFN Type I IFN Type I IFN Type I IFN Type I IFN Type I IFN Type I IFN Antiviral Source: All cell types, mostly by pDC Antimicrobial Regulation of innate and adaptive immunity pDC Apoptosis Proliferation Differentiation Angiogenesis

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